Radiation-induced angiosarcoma of the vagina and vulva: Case report and review of literature

Khaled, Chirine; Sinno, Sara

doi:10.1016/j.gore.2022.100990

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…The high-risk HPV, which is responsible for many cervical cancers, is well-known to cause vaginal and vulva squamous carcinomas. It is also necessary to monitor these patients, as radiotherapy commonly used to treat locally invasive cervical cancers can cause secondary malignant tumours unrelated to HPV 17,18 infection. One of these is angiosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Vulva lesions seen at a tertiary health centre in southwest Nigeria

Olaofe OO

2024

Ibom Med J

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Background: Some researchers have emphasised the need for more studies on vulvar cancers. The aim of our study is to describe the vulvar lesions identified in biopsies seen in our department over a five-year period to serve as baseline data for future studies. Methods: We conducted a five-year cross-sectional study on all vulva specimens received by the department of Morbid Anatomy and Forensic medicine at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. From the departmental records, we retrieved data on the patients' biodata, medical history, and vulva lesion diagnosis. Results: We recorded 15 vulva biopsies during the study period, with an age range of 13 to 80 years. Two cases were benign tumours, and two cases were inflammatory in nature. A case of a pre-malignant lesion was seen. Nine cases were malignant tumours, all of which are epithelial in origin. We saw two non-neoplastic lesions. These are acute on chronic inflammation and lichen sclerosus et atrophicus. Of the malignant tumours seen, five were well-differentiated squamous cell carcinoma (SCC), two were moderately differentiated SCC, and two were cases of verrucous carcinoma. One case of verrucous carcinoma and a well-differentiated SCC had a background HIV. Conclusion: Vulva lesions are rarely seen at our centre. The absence of preinvasive lesions in our study may be due to the late presentation of cases in clinics or the reluctance of gynaecologists to take biopsies of non-tumoral lesions of the vulva. HIV may be associated with an increased risk of HPV-related cancers.

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Section: Discussionmentioning

confidence: 99%

Vulva lesions seen at a tertiary health centre in southwest Nigeria

Olaofe OO

2024

Ibom Med J

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“…High rates of recurrence have also been associated with these tumors. Factors associated with the dismal prognosis for these tumors include advanced age, large size, increased mitotic activity, tumor necrosis, epithelioid morphology, and positive resection margins [ 11 ]. However, none of these associations have been validated by other studies.…”

Section: Discussionmentioning

confidence: 99%

Primary Vaginal Epithelioid Angiosarcoma: A Case Report and Literature Review of a Rare Neoplasm

Ahmad¹,

Warren²,

Ingyin³

et al. 2023

Cureus

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Angiosarcoma is a malignant neoplasm showing morphological or immunophenotypic evidence of endothelial differentiation with either a vascular or lymphatic origin. It has a strong predilection for skin and deep soft tissue. Angiosarcomas of the gynecologic tract are very uncommon, and very few cases have been described in medical literature up to this day. Primary vaginal angiosarcomas with no prior history of radiation are exceedingly rare. The epithelioid subtype of primary vaginal angiosarcomas is even more uncommon. Here we present a rare case of an epithelioid subtype of primary vaginal angiosarcoma in a 47-year-old woman with no prior history of radiation who presented with pelvic pain, malodorous vaginal discharge, and a vaginal mass.

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Paclitaxel

2022

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Radiation-induced angiosarcoma of the vagina and vulva: Case report and review of literature

Cited by 6 publications

References 29 publications

Vulva lesions seen at a tertiary health centre in southwest Nigeria

Vulva lesions seen at a tertiary health centre in southwest Nigeria

Primary Vaginal Epithelioid Angiosarcoma: A Case Report and Literature Review of a Rare Neoplasm

Paclitaxel

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