Radiation-induced basal cell carcinoma

Zargari, Omid

doi:10.5826/dpc.0502a22

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…In the literature, an often pigmented nodular appearance has been reported, which is specific to both primary and radio-induced BCCs. 4,14 All the authors agree that BCC is the predominant histological type for both radiation-induced skin tumours and primary skin tumours. 5,9,[12][13][14] Our series nevertheless reported a good number of squamous cell carcinomas, that is, 25 lesions in 20 patients (12•5%).…”

Section: Discussionmentioning

confidence: 86%

“…4,14 All the authors agree that BCC is the predominant histological type for both radiation-induced skin tumours and primary skin tumours. 5,9,[12][13][14] Our series nevertheless reported a good number of squamous cell carcinomas, that is, 25 lesions in 20 patients (12•5%). We have even reported cases of adnexal tumours.…”

Section: Discussionmentioning

confidence: 86%

“…This risk of new basal cell carcinomas is classic for sporadic basal cell carcinomas and is increased for radio-induced BCCs. 14,19 Karagas et al reported a relative risk (RR) equal to three for developing a new lesion in subjects irradiated for ringworm. 17 It therefore seems essential to us to stress to patients the importance of regular follow-up with careful clinical monitoring in order to diagnose any relapses in time and thus ensure the patient is receiving adequate treatment.…”

Section: Discussionmentioning

confidence: 99%

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Radio-induced malignancies of the scalp in adult after depilatory radiotherapy for tinea capitis in childhood: 137 cases

et al. 2022

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Introduction: Radiation-induced malignancies are the most feared complications of radiotherapy. Depilatory radiotherapy for ringworm of the scalp in childhood was the cause of an increase in the incidence of skin tumours of the scalp in adults. The aim of our study was to describe the epidemiological, clinical and therapeutic characteristics of radiation-induced skin tumours of the scalp in order to highlight the characteristics of these tumours compared to non-radiation-induced tumours. Methods: This is a bi-centric retrospective study, extending over a period of 41 years, which collected 137 patients with 200 tumours of the scalp. These patients were selected after noting a history of depilatory radiotherapy for ringworm in childhood in the clinical records of all patients with scalp tumours. We studied the epidemiological, clinical, therapeutic and evolving characteristics of this population. Results: The average age of consultation was 56·6 years. The sex ratio M/F was 3. Radiation dermatitis was found in 33% of cases. The average latency between depilatory radiotherapy and the appearance of radiation-induced tumours was 42·6 years. Multiple carcinomas (>2 tumours) were observed in 23·3% of cases. In 73% of cases, ulceration was the most frequent macroscopic aspect. The predominant histological type was basal cell carcinoma in 82% of cases. Radiation therapy has been the main treatment modality in 77·3% of cases, followed by surgery in 43% of cases. The appearance of new tumours on the scalp was observed in six patients. Conclusion: Radiation-induced tumours of the scalp are comparable in epidemiological and clinical characteristics to non-radiation-induced tumours. However, they may represent a challenge in therapeutic care and require regular monitoring.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Radio-induced malignancies of the scalp in adult after depilatory radiotherapy for tinea capitis in childhood: 137 cases

et al. 2022

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“…2,6,8,9 Post-radiotherapy BCCs are often multiple and typically occur after a long latency period, usually of several decades. [2][3][4]6 It has also been described that BCCs of the scalp arising in this setting demonstrate more aggressive behaviour, with a higher rate of recurrences, often demanding more aggressive surgical excision, 10 although this assertion has been challenged due to methodological issues. 11 Another study found that, despite a high proportion of histologically aggressive cases, there was no apparent aggravation of their biological behaviour.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinomas of the scalp after radiotherapy for tinea capitis: Clinicopathological study in a case series of 96 patients with analysis of 427 tumours

et al. 2022

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Background/Objectives: Low-dose X-ray radiotherapy to treat tinea capitis during childhood is a well-known risk factor for scalp basal cell carcinomas (BCCs). Post-radiotherapy BCCs are often multiple, and it has been suggested that they display more aggressive features. Our main objective was to study the clinicopathological aspects of post-radiotherapy BCCs to evaluate their biological behaviour and identify features that may differ from other BCCs. Methods:We performed an observational, retrospective study assessing multiple clinical and pathological characteristics of patients with post-radiotherapy BCCs. Results:We studied 96 patients with 427 post-radiotherapy scalp BCCs. Postradiotherapy BCCs were often multiple (median of 4 lesions/patient, ranging from 1 to 54). Significant comorbidities included a high incidence of thyroid disease and meningiomas. Recurrences were observed in 23% of patients, but there may be confounding factors, such as referral bias, heterogenous treatment modalities and occurrence of new tumours due to field effect. We found a high incidence of infundibulocystic BCCs (in 14.6% of patients and corresponding to 5.4% of the total number of tumours), trichoblastomas (5.2%) and neurofibromas of the scalp (10%). Conclusions:This study is consistent with the occurrence of multiple lesions (sometimes numerous) and a relatively high tendency for recurrence in postradiotherapy BCCs, as suggested by previous studies. We also found a high incidence of the infundibulocystic variant and a higher risk of follicular tumours and neurofibromas, which suggests that radiotherapy may influence the type of differentiation of BCCs and contribute to induce neoplasms of different cell lines.

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“…However, in patients with a history of radiation treatment, the prevalence of BCC is higher than in patients with no history of radiation treatment [7][8][9]. Moreover, several reports have characterized radiogenic BCC as gen-erally more aggressive, difficult to excise completely, and more likely to recur than non-radiogenic BCC [9,10]. Therefore, it is important to conduct a close physical examination, especially of areas previously exposed to radiation, in patients with a history of radiation treatment [7][8][9]11].…”

Section: Introductionmentioning

confidence: 99%

A rare case of abdominal adenoid basal cell carcinoma in a patient with a history of radiation therapy

Kim

Cheon

2020

Arch Plast Surg

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Basal cell carcinoma (BCC) is the most common skin cancer and its incidence is steadily increasing. Prior radiation therapy is one of the most important risk factors for BCC. Although the mechanism remains undefined, long-term studies have shown that people exposed to radiation have an increased risk of BCC. Despite the fact that BCC occurs most frequently in sun-exposed areas of the body, patients with a history of radiation therapy have an increased risk of BCC in areas previously exposed to radiation. Here, we report a case of adenoid BCC on the abdomen in a 67-year-old woman after radiation therapy post-hysterectomy.

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Radiation-induced basal cell carcinoma

Cited by 11 publications

References 10 publications

Radio-induced malignancies of the scalp in adult after depilatory radiotherapy for tinea capitis in childhood: 137 cases

Radio-induced malignancies of the scalp in adult after depilatory radiotherapy for tinea capitis in childhood: 137 cases

Basal cell carcinomas of the scalp after radiotherapy for tinea capitis: Clinicopathological study in a case series of 96 patients with analysis of 427 tumours

A rare case of abdominal adenoid basal cell carcinoma in a patient with a history of radiation therapy

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