Radiation-Induced Bystander Effects and Stress-Induced Mutagenesis

Mothersill, Carmel; Seymour, Colin

doi:10.1007/978-1-4614-6280-4_10

Cited by 5 publications

(6 citation statements)

References 168 publications

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“…1 Stress can be considered any disturbance (chemical, physical, or biological), that inflicts damage, disrupts homeostasis or elicits compensatory responses. 1 -3 Stress responses can resist or suppress stressors and improve or stabilize organismal and cellular functions. 1,2 However, if stress is prolonged or tolerance is exceeded, dysfunction and damage may result.…”

Section: Introductionmentioning

confidence: 99%

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Fuciarelli

Rollo

2020

Dose-Response

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Animals exposed to significant stress express multi-modal responses to buffer negative impacts. Trans-generational impacts have been mainly studied in maternal lines, with paternal lines having received less attention. Here, we assessed paternal generational effects using irradiated male crickets ( Acheta domesticus), and their F1 offspring (irradiated males mated to unirradiated females). Paternal transmission of radiation impacts emerged in multiple life history traits when compared to controls. Irradiated males and their F1 offspring expressed hormetic responses in survivorship and median longevity at mid-range doses. For F0 males, 7 Gy & 10 Gy doses extended F0 longevity by 39% and 34.2% respectively. F1 offspring of 7 Gy and 10 Gy sires had median lifespans 71.3% and 110.9% longer, respectively. Survivorship for both F0 7 Gy (p < 0.0001) and 10 Gy (p = 0.0055) males and F1 7 Gy and 10 Gy (p < 0.0001) offspring significantly surpassed that of controls. Irradiated F0 males and F1 offspring had significantly reduced growth rates. For F0 males, significant reductions were evident in 4Gy-12 Gy males and F1 offspring in 4 Gy (p < 0.0001), 7 Gy (p < 0.0001), and 10 Gy (p = 0.017). Our results indicate paternal effects; that irradiation directly impacted males but also mediated diverse alterations in the life history features (particularly longevity and survivorship) of F1 offspring.

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Section: Introductionmentioning

confidence: 99%

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Fuciarelli

Rollo

2020

Dose-Response

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“…The RIBE effectively enlarges the target for radiation effects through ''horizontal transmission'' to enlarge the affected population size, whereas RIGI enlarges the target for radiation effects through ''vertical transmission'' to draft the progeny into the affected population [10]. Both the RIBE and RIGI lead to damage in the affected population, which is similar to radiation damage.…”

Section: Definition and History Of Rigimentioning

confidence: 97%

“…RIGI can be observed in progeny, which are many generations after the initial irradiated cells, whereas RIGI had not been detected in the irradiated cells themselves or their immediate progeny, which are unstable and mutation-prone but appear to be healthy [10,49,64,86,[93][94][95]. RIGI in in vitro experiments has been extensively studied and reviewed [64,76,79,[96][97][98][99].…”

Section: Definition and History Of Rigimentioning

confidence: 98%

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Embryos of the zebrafish Danio rerio in studies of non-targeted effects of ionizing radiation

Choi

2015

Cancer Letters

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“…Radiation-induced genomic instability (RIGI) referred to delayed lethal mutations or reproductive cell death, as well as elevations in the rate of de novo appearance of chromosomal aberrations and gene mutations, in the progeny of irradiated cells [37,38,39,40,41]. RIGI could be observed in progeny which were many generations after the initial irradiated cells, while the irradiated cells themselves or their immediate progeny could appear healthy but were in fact unstable and mutation-prone [13,42,43,44,45,46]. Changes in gene profiles induced by IRs were widely characterized through microarray hybridization techniques [47,48] with enhanced detection accuracy of differential expression [49].…”

Section: Ionizing Radiation Targeted Effects and Non-targeted Effmentioning

confidence: 99%

Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation

Kong

Cheng

2016

IJMS

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Exposure to ionizing radiations (IRs) is ubiquitous in our environment and can be categorized into “targeted” effects and “non-targeted” effects. In addition to inducing deoxyribonucleic acid (DNA) damage, IR exposure leads to epigenetic alterations that do not alter DNA sequence. Using an appropriate model to study the biological effects of radiation is crucial to better understand IR responses as well as to develop new strategies to alleviate exposure to IR. Zebrafish, Danio rerio, is a scientific model organism that has yielded scientific advances in several fields and recent studies show the usefulness of this vertebrate model in radiation biology. This review briefly describes both “targeted” and “non-targeted” effects, describes the findings in radiation biology using zebrafish as a model and highlights the potential of zebrafish to assess the epigenetic effects of IR, including DNA methylation, histone modifications and miRNA expression. Other in vivo models are included to compare observations made with zebrafish, or to illustrate the feasibility of in vivo models when the use of zebrafish was unavailable. Finally, tools to study epigenetic modifications in zebrafish, including changes in genome-wide DNA methylation, histone modifications and miRNA expression, are also described in this review.

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Radiation-Induced Bystander Effects and Stress-Induced Mutagenesis

Cited by 5 publications

References 168 publications

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Embryos of the zebrafish Danio rerio in studies of non-targeted effects of ionizing radiation

Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation

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