2014
DOI: 10.1097/hp.0000000000000158
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Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies

Abstract: The threat of a large scale radiological emergency, where thousands of people may require fast biological dosimetry for the purpose of triage, makes it necessary to search for new, high throughput biological dosimeters. The authors tested an assay based on the quantitative analysis of selected proteins in peripheral blood serum. They were particularly interested in testing proteins that are specific to irradiation of skin, as these can be used in cases of partial body exposure. Candidate proteins were identifi… Show more

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Cited by 11 publications
(10 citation statements)
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References 33 publications
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“…It has become clear that RT and RCT do have the potential to change the tumor and its microenvironment (33) and that radiation exposure is reflected locally and systemically (34). Innovative IT approaches should consider the dynamics of radiation-induced immune cell infiltration into tumors since the immune cells should be activated in the modified environment.…”
Section: Discussionmentioning
confidence: 99%
“…It has become clear that RT and RCT do have the potential to change the tumor and its microenvironment (33) and that radiation exposure is reflected locally and systemically (34). Innovative IT approaches should consider the dynamics of radiation-induced immune cell infiltration into tumors since the immune cells should be activated in the modified environment.…”
Section: Discussionmentioning
confidence: 99%
“…found an increased up-regulation of genes involved in the glycolysation in liver and increased serum cytokines, suggesting a systemic response to local irradiation of the skin to 20, 40, and 80 Gy gamma rays. Analysis of three proteins (Apol (please correct spelling should read: Apolipoprotein)ipprotein E, Factor X and Panththenate Kinase 4) in blood samples allowed discrimination up to 1 month following exposure to <2 Gy and >10 Gy in breast cancer patients, although differences at < 2 Gy were subtle [167]. Similarly [168] found that changes in serum amyloid A (SAA) levels permitted a dose prediction model to discriminate ≤1 Gy from ≥2 Gy irradiated mice.…”
Section: Biomarkers Related To Changes In Protein Levelsmentioning
confidence: 99%
“…78 Serial secondary triage in rearward treatment facilities would focus on clinical, serial hematological and other advanced biological parameters (eg, protein biomarkers for better triage accuracy than one biomarker alone). 78,87 Triage decisions will optimize opportunities for both direct casualty care and mitigation of indirect or preventable mortality and morbidity. Well researched triage tools and cards leading to treatment guidance are readily available.…”
Section: Nuclear Triage Centersmentioning
confidence: 99%