Radiation hardening should be considered for various active fiber systems operated in adverse environments to reduce their sensitivity to complex ionizing radiations. And, architecture optimization through numerical simulation provides an efficient choice. Here, introducing radiation effects into the conventional fiber laser model, a radiation model concerning the design optimization of low- and moderate-power Yb-doped fiber lasers is developed. And, experiments at different radiation levels up to 750 Gy are carried out for validation, demonstrating the ability of this model to correctly simulate the performance of the Yb-doped fiber laser in harsh environments. Then, with this model, impacts of active fiber length, pump scheme, and pump allocation on the output characteristics of Yb-doped fiber lasers are analyzed numerically. And, optimization of Yb-doped fiber lasers are conducted through architecture design. Simulations show that a proper design with relatively short active fiber and dynamic pump allocation can remarkably improve the radiation tolerance of Yb-doped fiber lasers.