Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report

Abstract

Cutaneous angiosarcoma (CA) is a rare and aggressive malignant tumor that develops from vascular endothelium. Secondary CAs are often caused by radiotherapy and chronic lymphedema. Most radiation-induced CAs are associated with breast or gynecologic cancer. The prognosis of CA is extremely poor, with a 5-year survival rate ranging from 12% to 34%. Therapeutic options are limited, and surgical excision with negative margins remains the mainstay of treatment. We report a case of a 63-year-old woman who developed secondary CA at an irradiated site 7 years after receiving radiotherapy for cervical cancer.

Chondrosarcoma of the Pelvis after Radiotherapy for Cervical Cancer: A Case Report

“…The incisional biopsy reported a secondary high-grade chondrosarcoma, and the patient discontinued followup without accepting palliative chemotherapy. Consulted literature refers to RIS being commonly diagnosed late, being of high grade, and having a poor prognosis; surgery, when feasible, constitutes the treatment of choice, and overall survival rarely exceeds 2 years [2,3,[6][7][8]14].…”

“…For the group from 50 to +85 years, the incidence is in the 3rd position but has increased to 36.3 cases per 100,000 and is the 2nd cause of death by cancer with 21.4 cases per 100,000 [12]. While isolated cases of RIS in CC, such as leiomyosarcomas [13], cutaneous angiosarcomas [14], and rhabdomyoblastic sarcomas [4], have been the most common sarcomas reported in some series are undifferentiated pleomorphic sarcoma, angiosarcoma, and leiomyosarcoma [2,4]. The incidence of bone sarcomas in patients irradiated for CC who survive 5 years represents only 0.04% [3], significantly increasing in the first 20 years and decreasing thereafter [11,15].…”

Angiosarcoma after adjuvant radiotherapy in high-risk squamous cell carcinoma of the vulva: a case report

“…Radiation-induced angiosarcoma is considered a rare but serious late side-effect associated with radiation therapy for primary malignancies, including gynecological cancers. However, most of the cases described in the literature are associated with breast cancer, less with gynecological malignancies, particularly with vulvar cancer [17]. The use of new technologies allows the delivery of high doses of radiation therapy, significantly correlated with a better prognosis, but also potentially associated with rare significant morbidity such as secondary malignancies.…”