1977
DOI: 10.2307/3574686
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Radiation-Induced DNA Damage and Lethality in E. coli As Modified by the Antitumor Agent cis-Dichlorodiammineplatinum(II)

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Cited by 78 publications
(14 citation statements)
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“…The fact that cis-DDP enhanced the radiation response only when given before irradiation and decreased the Do for radiation alone may indicate a true radiosensitization. This hypothesis has previously been suggested in both in vivo and in vitro studies (Douple & Richmond, 1978and 1982Overgaard & Khan, 1981; Richmond & Powers, 1976;Richmond et al, 1977). A selective enhancement at drug administration before irradiation was also found using the mouse foot skin scoring system (von der Maase, 1984b).…”
Section: Crypt Survivalmentioning
confidence: 66%
“…The fact that cis-DDP enhanced the radiation response only when given before irradiation and decreased the Do for radiation alone may indicate a true radiosensitization. This hypothesis has previously been suggested in both in vivo and in vitro studies (Douple & Richmond, 1978and 1982Overgaard & Khan, 1981; Richmond & Powers, 1976;Richmond et al, 1977). A selective enhancement at drug administration before irradiation was also found using the mouse foot skin scoring system (von der Maase, 1984b).…”
Section: Crypt Survivalmentioning
confidence: 66%
“…Cisplatin is considered the most effective single agent as systemic therapy in eradicating micro metastasis and moreover as a radiosensitizer in uterine cervical carcinoma [14,15]. Cisplatin when simultaneously administered with radiotherapy, have radio sensitivity effects by inhibition of DNA synthesis, inhibition of transcription elongation by DNA inter strand cross-links, inhibition of repair of radiation induced DNA damage and increase the sensitivity of hypoxic cells and cell death [16][17][18][19]. About forty percent of total tumor dose is delivered in brachytherapy in uterine cervix and parametriums, and the minimum dose to the rectum and bladder can be achieved by accurate treatment planning.…”
Section: Discussionmentioning
confidence: 99%
“…5) appear parallel, which suggests that the two compounds show a degree of additivity that cannot be explained if they sensitize wholly by the same mechanism(s). DISCUSSION cis-Platinum complexes can increase the radiation sensitivity of cells in vitro under both aerobic and hypoxic conditions (Richmond & Powers, 1976;Szumiel & Nias, 1976;Nias & Szumiel, 1977;Richmond et al, 1977;Douple & Richmond, 1978) with the greatest effect apparently on the hypoxic cells (Richmond & Powers, 1976;Richmond et al, 1977;Douple & Richmond, 1978;Nias et al, 1979). In the present work 5tM cis-Pt(II) increases the radiation sensitivity of hypoxic mammalian cells, giving an ER of 1-12.…”
Section: Cytotoxicity 8tudiesmentioning
confidence: 99%
“…We are currently studying the cytotoxic effect of some common antineoplastic drugs, including a cis-Platinum complex, cis-dichlorodiammineplatinum-(II) (cis-Pt(II)). cis-Pt(II) is a proven cytotoxic agent (see Roberts & Thomson, 1979, for review) and can also act as a radiosensitizer of hypoxic cells (Richmond & Powers, 1976;Richmond et al, 1977;Douple & Richmond, 1978;Nias et al, 1979 Cytotoxicity experiments.-250ml spinner flasks were fitted with a gas inlet/outlet system and a sidearm through which samples could be withdrawn. Asynchronous, logphase cells at a concentration of 2 x 105/ml were suspended in MEM + 7.5 % FCS and held in a water bath at 37TC.…”
mentioning
confidence: 99%