Radiation-induced intracranial osteosarcoma

Patel, Richa; Gadgil, Nitin M; Khare, Manisha; Majethia, Nikhil

doi:10.4103/0022-3859.132379

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the head and neck region, it may occur in the mandible with an estimated incidence of 0.084% after irradiation for nasopharyngeal carcinoma (NPC),18 in the calvarium; or rarely, in the skull base 10 11. Of the 20 cases of radiation-induced osteosarcoma of the skull base (RIOSB) identified in the literature, the most common primary tumour was pituitary adenoma (35%), followed by craniopharyngioma (20%), retinoblastoma (15%), rhabdomyosarcoma (10%), squamous cell carcinoma of the nasal cavity (10%) and maxillary and adenoid cystic carcinoma (10%) 10 11 19–26. Echchikhi et al 10 reported the only case of skull base radiation-induced osteosarcoma after RT for NPC (5%).…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma

et al. 2021

View full text Add to dashboard Cite

Esthesioneuroblastoma (ENB) is an uncommon sinonasal cancer of the olfactory neuroepithelium that is typically treated with surgical resection followed by radiation therapy. Radiation-induced intracranial osteosarcoma of the skull base is a rare but devastating long-term complication of radiation therapy in this region. Here, we present a case of an 82-year-old patient who developed radiation-induced osteosarcoma of the anterior skull base and paranasal sinuses 10 years after radiation therapy following resection of an ENB. Older patients may be at risk of developing this complication earlier and with a worse prognosis relative to younger patients. Treating physicians/surgeons should be aware of this devastating complication. Patients who are treated with high-dose radiation therapy in this region should be followed for many years.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It is very rare but aggressive, with high recurrence and a poor prognosis [6]. The median overall survival time was reported to be 29 months [1].…”

Section: Introductionmentioning

confidence: 99%

A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy

et al. 2014

View full text Add to dashboard Cite

We treated a 54-year-old Japanese female with a recurrent radiation-induced osteosarcoma arising from left occipital skull, by reactor-based boron neutron capture therapy (BNCT). Her tumor grew rapidly with subcutaneous and epidural extension. She eventually could not walk because of cerebellar ataxia. The tumor was inoperable and radioresistant. BNCT showed a marked initial therapeutic effect: the subcutaneous/epidural tumor reduced without radiation damage of the scalp except hair loss and the patient could walk again only 3 weeks after BNCT. BNCT seems to be a safe and very effective modality in the management of radiation-induced osteosarcomas that are not eligible for operation and other treatment modalities.

show abstract

Primary and radiation induced skull base osteosarcoma: a systematic review of clinical features and treatment outcomes

Bin-Alamer

Haider

et al. 2021

J Neurooncol

View full text Add to dashboard Cite

Radiation-induced intracranial osteosarcoma

Cited by 6 publications

References 5 publications

Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma

Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma

A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy

Primary and radiation induced skull base osteosarcoma: a systematic review of clinical features and treatment outcomes

Contact Info

Product

Resources

About