Radiation-induced leiomyosarcomas as second primary tumors in the head and neck region: Report of 2 cases

Demirkan, Ferit; Ünal, Şakir; Çenetoğlu, Seyhan; Cinel, Leyla

doi:10.1053/joms.2003.50029

Cited by 21 publications

(18 citation statements)

References 15 publications

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“…Involvement of oropharynx was already described 38 years after radiotherapy for a squamous cell carcinoma of contralateral tonsil [20]. Furthermore, there were also cases affecting the oral cavity vicinity, such as a deep radiation-induced subcutaneous cheek LMS that had recurred on the base of the maxillary sinus and infiltrated the hard palate extending into the oral cavity [21] and a post-radiation cervical intranodal LMS following radiotherapy for a tongue squamous cell carcinoma [22]. A case of radiationassociated LMS involving subcutaneous tissues from the maxillofacial region was also described but the primary lesion was diagnosed as malignant fibrous histiocytoma, [23] a sarcoma recently renamed as undifferentiated pleomorphic sarcoma, an exclusion diagnosis that is commonly reclassified as other sarcoma, like LMS [2].…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy is the palliative option for inoperable lesions and metastatic diseases [3,21,26,30]. Five-year survival rates for oral LMS are about 60%, with worst prognosis for jawbone tumors [3,10,11,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Oral metastatic LMS has an overall poor prognosis, and patient usually dies from the disease in a short time interval or remains alive with controlled disease following radiotherapy and/or chemotherapy sessions [6][7][8]. Therefore, although the limited number of oral LMS turns not possible to standardize treatment modalities, it seems that aggressive surgical treatment is recommended for radical cure, and adjuvant radiotherapy and chemotherapy are used in order to obtain a reduced recurrence and an increased survival in all types of oral LMS [3,11,15,16,20,21,26], as carried out in these radiation-associated and metastatic-reported cases.…”

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Azevedo

Pires

Gouvêa

et al. 2011

Oral Maxillofac Surg

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Post-radiotherapy sarcomas of the oral cavity and oral metastasis from soft tissue sarcomas are very uncommon, but based on patient's clinical history, they should be considered by oral health care providers in order to allow an early diagnosis and proper and timely management. Finally, to the best of our knowledge, this seems to be the first reported case of tongue leiomyosarcoma arising in a previously irradiated field.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Azevedo

Pires

Gouvêa

et al. 2011

Oral Maxillofac Surg

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“…Sites of involvement are primarily the myometrium and the gastro-intestinal tract, followed by the soft tissue of the extremities and the retroperitoneum [ 1 ]. Leiomyosarcoma of the head and neck is rare, as smooth muscle is seldom encountered in this region, mainly in the walls of blood vessels and the erector pili musculature of the skin [ 8 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Radiation-induced leiomyosarcoma is an uncommon histological entity. Especially in the head and neck region, this radiation-associated malignant neoplasm represents an exceptional rarity [ 5 - 8 ].…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced leiomyosarcoma of the oropharynx

et al. 2006

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Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international literature, radiation-induced sarcoma arise in 0.035 to 0.2 % of all irradiated patients. Especially in the head and neck region, radiation-induced leiomyosarcoma is an extremely rare lesion. The authors report a case of a radiation-induced leiomyosarcoma of the tonsillar region of the oropharynx in a 51-year-old male patient, who had undergone radiation therapy of this region 38 years before. The lesion was treated by radical surgery. Diagnostic steps, histological presentation and therapy are described in detail and the literature concerning radiation induced malignancies in general as well as radiation induced leiomyosarcoma in particular is reviewed. The highlights of this case are an extremely uncommon location and a rare pathological entity of radiation induced malignancies.

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Oral radiation‐induced sarcomas: Systematic review

et al. 2020

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Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Results Forty‐two publications with 122 radiation‐induced sarcoma of the oral cavities (RISOCs) were included. The mean latency period was 114 months and mean radiation total dose was 62.5 Gy. The tumors were more prevalent in males between 50 and 60 years old and the mandible was the most affected site. Osteosarcoma was the most prevalent histological type and patients were mostly treated with radical surgery. Conclusions RISOC showed a poor survival rate of 15.1% in 5‐year follow‐up. Gender and histological type were independently associated with survival.

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Radiation-induced leiomyosarcomas as second primary tumors in the head and neck region: Report of 2 cases

Cited by 21 publications

References 15 publications

Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Radiation-induced leiomyosarcoma of the oropharynx

Oral radiation‐induced sarcomas: Systematic review

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