Radiation-induced lichen sclerosus of the vulva

Edwards, Lisa R.; Privette, Emily D.; Patterson, James W.; Tchernev, Georgi; Chokoeva, Anastasiya Atanasova; Wollina, Uwe; Lotti, Torello; Wilson, Barbara B.

doi:10.1007/s10354-016-0525-3

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…Therefore, repeatable irritation is believed to be a possible factor contributing to the disease. Another possible causal factor may be radiation [ 18 , 19 , 20 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

Pediatric Vulvar Lichen Sclerosus—A Review of the Literature

Orszulak

Dulska

Niziński

et al. 2021

IJERPH

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Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which may present in a prepubertal or adolescent patient. The most popular theories are its autoimmune and genetic conditioning, although theories concerning hormonal and infectious etiology have also been raised. The most common presenting symptoms of VLS is vulva pruritus, discomfort, dysuria and constipation. In physical examination, a classic “Figure 8” pattern is described, involving the labia minora, clitoral hood, and perianal region. The lesions initially are white, flat-topped papules, thin plaques, or commonly atrophic patches. Purpura is a hallmark feature of VLS. The treatment includes topical anti-inflammatory agents and long-term follow-up, as there is a high risk of recurrence and an increased risk of vulvar cancer in adult women with a history of lichen sclerosus. This article reviews vulvar lichen sclerosus in children and provides evidence-based medicine principles for treatment in the pediatric population. A systematic search of the literature shows recurrence of VLS in children. Maintenance regimens deserve further consideration.

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“…Therefore, repeatable irritation is believed to be a possible factor contributing to the disease. Another possible causal factor may be radiation [ 18 , 19 , 20 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

Pediatric Vulvar Lichen Sclerosus—A Review of the Literature

Orszulak

Dulska

Niziński

et al. 2021

IJERPH

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“…Of note is the fact that the large majority of reports relate to adjuvant radiotherapy of the breast. The numbers of cases reported in connection with head and neck cancer [ 8 ], endometrial carcinoma [ 9 ], vulva [ 10 ] or lymphomas [ 11 ] are significantly smaller. A pragmatic explanation might be the ease of clinical diagnosis and of the comparison between the irradiated and nonirradiated breast [ 12 ].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Radiation-induced morphea—a rare but severe late effect of adjuvant breast irradiation

et al. 2018

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BackgroundRadiation-induced morphea (RIM) is a circumscribed localized scleroderma that occurs most often in the breast. After an asymptomatic period of one month to several years, the symptoms (circumscribed inflammation, edema, sclerosis) often arise suddenly and cannot be clinically distinguished from a local recurrence in the form of inflammatory carcinoma.CaseWe present a case of a 74-year-old woman who developed this rare and serious local side-effect in connective tissue following neoadjuvant CDK 4/6 inhibitor abemaciclib (Verzenio®) and aromatase inhibitor anastrozole (Arimidex®) therapy and subsequent radiation therapy of the breast.ConclusionsLittle is known about risk factors and pathogenesis of RIM. Here we describe the first case of RIM following immunotherapy. The diagnosis is based on clinical appearance and histopathological examination. Treatment should be initiated in the inflammatory stage in order to prevent or delay irreversible fibrosis and atrophy of the breast.

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“…The timeframe between trauma and the onset of the disease ranges from months to years. 5,6 Intimate body piercing can cause local repeated trauma and persistent irritation, which, after a variable period, can lead to many complications such as a higher incidence of sexually transmitted diseases, cellulitis, abscesses, hypersensitivity reactions, bleeding, keloid formation, scarring, 7 and the appearance of a lichen sclerosus and symptoms that were observed in this patient.…”

mentioning

confidence: 86%