Radiation-induced malignant mesenchymoma of the chest wall following treatment for breast cancer.

Rustemeyer, P.; Micke, Oliver; Blasius, S.; Peters, P. E.

doi:10.1259/bjr.70.832.9166083

Cited by 14 publications

(6 citation statements)

References 13 publications

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“…MFHs are rare tumors, often characterized by an aberration in 7cen-q22 (38% of postirradiation MFHs). [57][58][59][60][61][62] Our incidence of MFH (1 of 27 patients with RIS) was lower than in other studies. 55,[63][64][65][66][67] For instance, Laskin et al 68 detected 36 MFHs among 53 patients with RIS.…”

Section: Discussionmentioning

confidence: 99%

Radiation‐induced sarcomas after radiotherapy for breast carcinoma

Kirova

Vilcoq

Asselain

et al. 2005

Cancer

237

171

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BACKGROUNDSarcomas are a rare complication of radiotherapy for breast carcinoma and patients have a poor prognosis. The incidence, histology, and management of patients with sarcomas were reviewed in the current study.METHODSThe authors reviewed the records of 16,705 patients with breast carcinoma. Of these, 13,472 (81%) were treated with megavoltage radiotherapy and 3233 were treated without at the Institute Curie (Paris, France) between 1981 and 1997. Median doses of 50–55 grays (Gy) in 25–27 fractions were delivered to the whole breast over a period of 5–5.5 weeks (2 Gy/day, 5 weekly fractions) followed, when indicated, by a 16–26‐Gy boost to the tumor or tumor bed. Treatment of radiation‐induced sarcomas (RIS) consisted mostly of radical surgery and chemotherapy.RESULTSOverall, 35 patients developed sarcomas. Of these, 27 fulfilled the Cahan criteria. The median follow‐up was 9.3 years (range, 1–22.4 years). The latency period ranged from 3 years to 20.3 years. Thirteen sarcomas were located in the breast, 5– in the chest wall, 3 in the sternum, 2 in the supraclavicle, 1 in the scapula, and 3 in the axilla. Histologic evaluation identified 13 angiosarcomas, 3 osteosarcomas, 5 undifferentiated sarcomas, 1 malignant fibrous histiocytoma, 2 leiomyosarcomas, 1 fibrosarcoma, 1 rhabdomyosarcoma, and 1 myosarcoma. The cumulative RIS incidence was 0.07% (± 0.02) at 5 years, 0.27% (± 0.05) at 10 years, and 0.48% (± 0.11) at 15 years. Standardized incidence ratios were 10.2 (95% confidence interval, 9.03–11.59) for irradiated patients and 1.3 (0.3–3.6) for nonirradiated patients. Of the 27 patients, 15 died of sarcoma within 1 month to 14.5 years (mean, 34.2 ± 0.7 months). The 5‐year actuarial survival rate after diagnosis of RIS was 36% (± 0.11).CONCLUSIONSThe current study confirmed the rarity of RIS. However, it showed that the risk increased with time. Therefore, careful, long‐term follow‐up of patients treated with radiotherapy is needed for early detection and efficacious treatment of these malignancies. Cancer 2005. © 2005 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Radiation‐induced sarcomas after radiotherapy for breast carcinoma

Kirova

Vilcoq

Asselain

et al. 2005

Cancer

237

171

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“…Acute and chronic changes may occur in the skin that has been radiated. In addition, benign and malignant neoplasms have been observed in the areas that have received radiotherapy 11–30 (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Malignant neoplasms localized to radiotherapy fields include non‐melanoma skin cancer, melanoma, leukemia/lymphoma, sarcoma and metastatic carcinoma – most commonly breast cancer 16–30 . The development of basal cell or squamous cell carcinoma in radiated skin is a late consequence that typically presents many years after the radiation treatment has been performed 16,23,25,28 .…”

Section: Discussionmentioning

confidence: 99%

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

Cohen

Prieto

2010

J Cutan Pathol

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Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woman who developed a solitary xanthogranuloma within the field of radiotherapy following treatment of her breast cancer is reported. In addition to xanthogranuloma, other benign lesions of keratinocytes, mast cells, endothelial cells and lymphatic cells have been observed at the site of radiation treatment. Also, several malignancies, including hematopoietic cancers, sarcomas, metastatic cancers and common skin cancers, have been observed within radiation ports. A causal relationship in the development of our patient's xanthogranuloma is suggested by the temporal association between the treatment with radiotherapy and the subsequent appearance of a xanthogranuloma directly within the radiation field.

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“…20 A radiationinduced malignant mesenchymoma has been considered in human medicine. 23 In the case described herein, chronic inflammation associated with foreign material could have played a role in tumor development. A previous case of neoplastic mesenchymal proliferation has been reported at the site of deep nonabsorbable suture placement in a cat.…”

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confidence: 83%

An Intra-Abdominal Malignant Mesenchymoma Associated with Nonabsorbable Sutures in a Ferret (Mustela Putorius Furo)

Petterino

Bedin²,

Vascellari

et al. 2010

J VET Diagn Invest

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Abstract. A 6-year-old ferret (Mustela putorius furo) was presented with abdominal enlargement. Clinical examination revealed an intra-abdominal mass measuring approximately 5 cm in diameter. Abdominal survey radiographs revealed a sharply marginated mass with multifocal radiodense foci, suggestive of pathologic calcification. A complete blood cell count revealed a moderate, normocytic, normochromic, nonregenerative anemia. The mass was surgically removed en bloc, fixed in 10% neutral buffered formalin solution, and routinely processed for histologic and immunohistochemical investigation. The neoplastic tissue consisted of a mixed neoplastic cell population, including osteosarcoma and fibrosarcoma components. Immunohistochemistry revealed that both neoplastic cell populations were positive for vimentin and negative for actin (smooth and striated), desmin, and myoglobin. Nonabsorbable suture material was admixed with the neoplastic tissue in the histologic section. This material was birefringent when viewed microscopically under polarized light.

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Radiation-induced malignant mesenchymoma of the chest wall following treatment for breast cancer.

Cited by 14 publications

References 13 publications

Radiation‐induced sarcomas after radiotherapy for breast carcinoma

Radiation‐induced sarcomas after radiotherapy for breast carcinoma

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

An Intra-Abdominal Malignant Mesenchymoma Associated with Nonabsorbable Sutures in a Ferret (Mustela Putorius Furo)

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