Radiation-induced meningiomas in pediatric patients

Moss, S. David; Rockswold, Gaylan L.; Chou, Shelley N.; Yock, Douglas H.; Berger, Michel S.

doi:10.1097/00006123-198804000-00026

Cited by 24 publications

(21 citation statements)

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“…In the present series, 3 out of 33 patients (9.1%) had neurofibromatosis. The meningiomas were documented to arise following previous irradiation for various indications [14, 15]. None of our patients had received irradiation in the past.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

et al. 2007

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Aim: Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5–1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. Methods: From 1990 to 2005, 33 patients belonging to the pediatric age group with intracranial meningiomas were treated in NIMHANS. Results: There were 19 male and 14 female children. The duration of symptoms ranged from 1 to 60 months. The study had a mean follow-up of 23.4 months. The commonest presenting symptoms were headache (90.9%) and visual disturbances (51.5%). Three patients had associated neurofibromatosis. Calcification was noticed in 22% of the tumors. Intraventricular meningiomas were the commonest (24.2%). Gross total or near total resection was possible in 22 out of 33 patients. Nine patients had reversible postoperative motor deficits. Fibrous meningioma was the commonest histological subtype (24.2%). Five patients had atypical or anaplastic subtypes. Adjuvant radiotherapy was administered in 4 patients. Six patients had recurrences and underwent surgery. Ten patients required either staged procedures or multiple surgeries for the recurrence/residual tumors. Conclusion: Pediatric meningiomas are rare tumors and differ from those in adults by their male predominance, atypical locations, higher rates of malignant subtypes, recurrence and association with neurofibromatosis. Surgical management is challenging because of atypical location.

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Section: Discussionmentioning

confidence: 99%

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

et al. 2007

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“…Our patient was diagnosed of a symptomatic meningioma 20 years after the radiotherapy received for his Rb. Despite the long latency, this tumor is likely to be radio-induced in the context of a genetically predisposed patient [13].…”

Section: Discussionmentioning

confidence: 99%

Low penetrance hereditary retinoblastoma in a family: what should we consider in the genetic counselling process and follow up?

et al. 2011

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Hereditary retinoblastoma (Rb) is a high penetrance autosomal dominant disease showing not only an increased risk of suffering bilateral Rb but also other second neoplasms. However, some families show a low-penetrance phenotype with reduced expressivity and incomplete penetrance of the retinoblastoma gene (RB1). Given the lack of specific guidelines for the follow-up of adult patients with hereditary Rb, the authors present a case report of a family with a low-penetrance phenotype and review the recommended surveillance in this setting, stressing the difficulties found in the genetic counselling process and follow up. Thus, since patients are at an increased risk, lifelong regular medical surveillance to detect any second malignancy at a stage that can be cured is required. In addition, avoidance of DNA-damaging agents and genetic testing should be considered for a throughout management of these families.

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“…Most spinal meningiomas are sporadic; however, some conditions such as neurofibromatosis type 2, Gorlin syndrome and exposure to ionizing radiation are associated with an increased risk for the development of meningiomas [35,36,37,38]. In the present case, these conditions were excluded.…”

Section: Discussionmentioning

confidence: 99%

Intradural Spinal Meningioma in a 20-Month-Old Female

et al. 2008

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Meningiomas in children account for less than 2% of all meningiomas, and their location in the spinal region is even less common. The authors present a case of a 20-month-old female who presented with lumbar back pain, neurogenic bladder and progressive paraparesis 6 months after she started to walk. Magnetic resonance imaging demonstrated an intradural extramedullary neoplasm extending from the tenth thoracic vertebra to the third lumbar vertebra. Complete excision of the tumor was performed by means of laminoplasty and the patient had a satisfactory postoperative recovery. Pathology and immunohistochemical studies diagnosed psammomatous meningioma.

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Radiation-induced meningiomas in pediatric patients

Cited by 24 publications

References 0 publications

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

Low penetrance hereditary retinoblastoma in a family: what should we consider in the genetic counselling process and follow up?

Intradural Spinal Meningioma in a 20-Month-Old Female

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