Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect

Akagündüz, Özlem Özkaya; Yılmaz, Suzan Güven; Tavlayan, Emin; Barış, Mine Esen; Afrashi, Filiz; Esassolak, Mustafa

doi:10.4143/crt.2021.575

Cited by 21 publications

(12 citation statements)

References 16 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,4 The microvascular alterations are associated with a reduction of retinal oxygenation, blood flow, and ischemia. [2][3][4] Contrast sensitivity decrease and visual field impairment were notified in patients treated with radiotherapy. 1 Our patient had gradually decreased bilateral visual acuity, as well as cataract and optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…1 The proximity with orbit tissues exposes them to severe damages. 2 However, late-onset, sight-threatening ocular complications may occur, including cataract, optic neuropathy, radiation retinopathy (RR), and ocular surface disease. 2 The early diagnosis of these lesions allowed to better prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…2 However, late-onset, sight-threatening ocular complications may occur, including cataract, optic neuropathy, radiation retinopathy (RR), and ocular surface disease. 2 The early diagnosis of these lesions allowed to better prognosis. 1 The optical coherence tomography angiography (OCT-A) allowed to investigate neovascular alteration for patients suffering from RR even before the inset of loss of vision.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Case Report: Optical coherence tomography angiography findings in radiation retinopathy

Ammari¹,

Zaghdoudi²,

Berriche³

et al. 2022

F1000Res

View full text Add to dashboard Cite

We report the observation of a 31-year-old patient followed for a nasopharyngeal carcinoma since 2009, treated by locoregional radiotherapy, with a cumulative dose of 70 Gray. This case presented all ocular complications of radiotherapy; radiation retinopathy (RR), which is the most severe complication, could be diagnosed earlier and have a better prognosis if optic coherence tomography angiography (OCTA) was performed. She presented with a progressive decline in bilateral visual acuity. Ophthalmologic examination revealed bilateral posterior subcapsular cataract, radiation retinopathy, and optic neuropathy. The OCT B-scan showed more pronounced macular edema in the right eye. The OCTA revealed enlargement of the central avascular zone and loss of the deep and superficial retinal vascular network. The patient received three consecutive monthly intravitreal injections of anti-vascular endothelial growth factor (VEGF), without improvement in visual acuity. The aim of this case report is to present the contribution of OCT-A in the diagnosis of radiation maculopathy, and attribute these changes to ischemia at the level of the retinal vascular network.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Case Report: Optical coherence tomography angiography findings in radiation retinopathy

Ammari¹,

Zaghdoudi²,

Berriche³

et al. 2022

F1000Res

View full text Add to dashboard Cite

show abstract

“… Forest plot of studies that reported radiation-induced retinopathy events [ 1 , 7 , 21 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 44 , 45 , 46 , 47 , 48 , 49 ]. …”

Section: Figurementioning

confidence: 99%

Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review

Kinaci-Tas

Alderliesten

Verbraak

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: Patients with brain, head, and neck tumors experience a decline in their quality of life due to radiation retinopathy and optic neuropathy. Little is known about the dose–response relationship and patient characteristics. We aimed to systematically review the prevalence of radiation retinopathy and optic neuropathy. Method: The primary outcome was the pooled prevalence of radiation retinopathy and optic neuropathy. The secondary outcome included the effect of the total radiation dose prescribed for the tumor according to the patient’s characteristics. Furthermore, we aimed to evaluate the radiation dose parameters for organs at risk of radiation retinopathy and optic neuropathy. Results: The pooled prevalence was 3.8%. No retinopathy was reported for the tumor’s prescribed dose of <50 Gy. Optic neuropathy was more prevalent for a prescribed dose of >50 Gy than <50 Gy. We observed a higher prevalence rate for retinopathy (6.0%) than optic neuropathy (2.0%). Insufficient data on the dose for organs at risk were reported. Conclusion: The prevalence of radiation retinopathy was higher compared to optic neuropathy. This review emphasizes the need for future studies considering retinopathy and optic neuropathy as primary objective parameters.

show abstract

“…[14] Radyasyon retinopati sıklıkla radyasyon keratopatisi, katarakt ve radyasyon optik nöropatisi gibi radyoterapinin diğer oküler komplikasyonları ile birlikte bulunabilir. [15,16]…”

Section: Introductionunclassified

Radiation Retinopathy: Pathogenesis, Diagnosis, and Treatment

2023

Güncel Retina (Current Retina)

View full text Add to dashboard Cite

Radiation retinopathy is chronic retinopathy that usually after radiotherapy with delayed onset (6 months-3 years) and slow progression. The primary vascular event is endothelial cell loss. Clinically affected individuals may be asymptomatic or may describe decreased visual acuity. Combining anamnesis, complete ophthalmologic examination, and multimodal imaging is essential for diagnosis. The ophthalmological examination may reveal signs of retinal vascular disease such as microaneurysms (the first structural change detected ophthalmoscopically), cotton wool spots, retinal hemorrhages, perivascular sheathing, capillary telangiectasia, macular edema, and optic nerve head edema. Optical coherence tomography can detect macular edema, intraretinal hyperreflective spots that may develop secondary to ischemia, disorganization in the inner retinal layers, and deterioration in the outer retina. Fundus fluorescein angiography helps detect capillary perfusion anomalies and other signs of vascular disease. Diabetic retinopathy, retinal vein occlusion, ocular ischemic syndrome, hypertensive retinopathy, Coats' disease, and parafoveal telangiectasia should be considered in the differential diagnosis, and sometimes these diseases may accompany radiation retinopathy. Currently, there is still no standard treatment for radiation retinopathy. Anti-vascular endothelial growth factors (anti-VEGF) and steroid therapy are among the effective treatment options. Retinal laser photocoagulation can be applied for neovascular complications. For macular edema, focal laser photocoagulation was less effective than anti-VEGF and steroid therapy in terms of functional gain.

show abstract

Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect

Cited by 21 publications

References 16 publications

Case Report: Optical coherence tomography angiography findings in radiation retinopathy

Case Report: Optical coherence tomography angiography findings in radiation retinopathy

Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review

Radiation Retinopathy: Pathogenesis, Diagnosis, and Treatment

Contact Info

Product

Resources

About