Radiation-induced spinal glioblastoma multiforme

Yeung, Yang; Wong, George Kwok Chu; Zhu, Xian Lun; B.Y., Brigette; Hk, Ng; Poon, Wai-sang

doi:10.1080/02841860500341124

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…Histomorphologically, spinal and cerebral glioblastomas are identical, with a comparable increase in the proliferation and accumulation of p53 protein seen on immunohistochemical studies 1. Survival times also appear similar.…”

Section: Discussionmentioning

confidence: 64%

“…Spinal GBM is rare, accounting for approximately 1.5% of all spinal cord tumours 1. There is a predilection toward the second and third decades of life, and it mainly appears in the cervical or thoracic segments 2…”

Section: Discussionmentioning

confidence: 99%

“…Spinal glioblastoma multiforme (GBM) is uncommon, accounting for 1%–5% of all glioblastoma cases 1. While there is predilection towards cervical location in younger patients,2 only two descriptions of cervical GBM (CGBM) have been published in the elderly 3 4.…”

Section: Introductionmentioning

confidence: 99%

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Cervical spinal glioblastoma multiforme in the elderly

Shastin

Mathew²,

Ismail

et al. 2017

BMJ Case Reports

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Spinal glioblastoma multiforme (GBM) is uncommon, and its diagnosis may be challenging. This is especially true in the elderly population. Best management strategy remains to be defined. The purpose of this report is to document this rare condition, increase awareness (as a potential differential diagnosis) and propose treatment options in the elderly; a review of the relevant literature is included. A biopsy may be beneficial in given circumstances as cervical spinal GBM carries a better prognosis compared with intramedullary metastasis.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Cervical spinal glioblastoma multiforme in the elderly

Shastin

Mathew²,

Ismail

et al. 2017

BMJ Case Reports

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“…Spontaneous spinal cord astrocytomas are most often low grade, and typically have a good prognosis, with an overall 5-year survival rate of between 70% -90% [17]. The survival rate of RI gliomas appears to be worse, which may correspond with their higher grade [15]. Of the 5 patient's in Table 1 with RI GBMs of the spinal cord, none survived longer than 8 months, compared to the median survival of 10 -12 months in patients with spontaneous spinal cord GBMs [31].…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Spinal Glioblastoma Multiforme: A Rare Complication in the Management of Head and Neck Cancer

Ju¹,

Robins²,

Salamat³

et al. 2016

IJOHNS

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Background: Radiation-induced gliomas of the spinal cord are rare late complications of spinal cord irradiation that typically occur in patients treated at younger ages. Aim: Raise awareness of radiation induced high grade gliomas with a case presentation and a review of the literature. Case Presentation: A 50-year-old male with Stage IVA squamous cell carcinoma of the oropharynx was treated with external beam radiotherapy with a complete response. Seven years later, he presented with a cervical spinal cord mass on MRI. An open biopsy was performed. Pathology revealed an intramedullary WHO grade IV astrocytoma, (i.e., glioblastoma multiforme) of the cervical spine that fulfilled the criteria for a radiation-induced malignancy. Conclusions: Review of the literature suggests that radiation-induced gliomas tend to be high grade and may occur at the periphery of an irradiated field. Radiation-induced gliomas of the spinal cord are a serious complication of radiotherapy that may occur in older patients with head and neck cancers, but are so rare that it should not affect treatment decisions.

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“…8) Only eight cases of radiation-induced spinal cord glioma have been reported since the first case in 1980 (Table 1). 2,4,7,13,15,18,21,24) Survival is very limited in these cases, regardless of various combinations of surgical resection, radiotherapy, and chemotherapy. Only 2 cases of spinal cord neoplasms have been reported following radiotherapy for testicular seminoma (peripheral nerve sheath tumor and angiosarcoma).…”

Section: Introductionmentioning

confidence: 99%

Radiation-Induced Spinal Cord Anaplastic Astrocytoma Subsequent to Radiotherapy for Testicular Seminoma

Kawanabe

Sawada

Yukawa

et al. 2012

Neurol. Med. Chir.(Tokyo)

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A 54-year-old man presented with a very rare case of radiation-induced intramedullary spinal cord anaplastic astrocytoma, which developed 37 years after radiotherapy for testicular seminoma. The patient presented with weakness and numbness of the left lower extremity that had gradually aggravated for 3 months. Magnetic resonance imaging demonstrated an intramedullary mass lesion with syringomyelia at the T9 to T12 levels. Subtotal removal of the tumor was performed using standard microsurgical technique. Histological examination revealed anaplastic astrocytoma. Although radiotherapy was seriously considered, chemotherapy was employed as adjuvant therapy considering the previous treatment. Although his neurological status improved transiently after surgery, relentless neurological decline occurred and resulted in death 9 months following surgery. Considering that subtotal removal of the tumor and chemotherapy had little influence on the quality of life and the length of survival in our case, cordectomy may be the optimum treatment for patients with radiation-induced spinal intramedullary malignant astrocytoma.

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Radiation-induced spinal glioblastoma multiforme

Cited by 14 publications

References 13 publications

Cervical spinal glioblastoma multiforme in the elderly

Cervical spinal glioblastoma multiforme in the elderly

Radiation-Induced Spinal Glioblastoma Multiforme: A Rare Complication in the Management of Head and Neck Cancer

Radiation-Induced Spinal Cord Anaplastic Astrocytoma Subsequent to Radiotherapy for Testicular Seminoma

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