Radiation-induced tumours of meninges. Report on eight cases and review of the literature

Kunert, Przemysław; Matyja, Ewa; Prokopienko, Marek; Marchel, Andrzej

doi:10.5114/ninp.2012.32099

Cited by 9 publications

(9 citation statements)

References 36 publications

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“…These events usually occur many years after the exposure. Several studies showed a latent period of 24–38 years, depending on the age at exposure, the dose levels, and the tumor type (Kunert, Matyja, Prokopienko, & Marchel, ; Schneider et al, ). Occasionally such an exposure was described to be associated with multiple tumors, rarely fulfilling NF2 diagnostic criteria (1/3,013 cases) (Sznajder et al, ).…”

Section: Discussionmentioning

confidence: 99%

Cranial irradiation in childhood mimicking neurofibromatosis type II

Bokstein

Dubov

Toledano‐Alhadef

et al. 2017

American J of Med Genetics Pt A

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Neurofibromatosis type II (NF2) is a genetic disease characterized by bilateral vestibular schwannomas (VS) and other nerve system tumors. However, such tumors may be associated with environmental, rather than a genetic, etiology. Individuals fulfilling the clinical criteria of NF2 who had been treated by head ionized irradiation at a young age were compared for disease characteristics and molecular analysis with non-irradiated sporadic NF2 cases. In the study cohort, three of 33 sporadic adult cases fulfilling NF2 diagnostic criteria had a history of early age cranial irradiation exposure. None of the irradiated patients had bilateral VS compared with 73.3% of the non-irradiated individuals. One of the irradiated patients had no VS, while none of the non-irradiated NF2 cases had absence of VS. All of the irradiated individuals had brain meningiomas and thyroid tumors compared with 47% and 0%, respectively, of the non-irradiated individuals. Molecular analyses for NF2 mutations in blood of the irradiated individuals failed to detect disease-causing mutations. This study suggest that environmental factors may mimic NF2. Identifying such non-genetic cases fulfilling clinical criteria of the genetic disease may be crucial for the purposes of genetic counseling and patient management.

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Section: Discussionmentioning

confidence: 99%

Cranial irradiation in childhood mimicking neurofibromatosis type II

Bokstein

Dubov

Toledano‐Alhadef

et al. 2017

American J of Med Genetics Pt A

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“…The 1920s provided the first reports of post-radiation sarcomas in patients, demonstrating evidence of the carcinogenic effects of radiation. 5,6 Following these reports, Cahan subsequently developed the original criteria for the diagnosis of a post-radiation malignancy (specifically sarcoma). This has most recently been revised by Al-Mefty et al 7 specifically for use with meningiomas and summarized in their manuscript as Table 1 (reproduced here): 1.…”

Section: Introductionmentioning

confidence: 99%

“…Tumor must not be present prior to radiation therapy The most frequent intracranial tumors resulting from irradiation are meningiomas, gliomas and sarcomas. 5 Postradiation meningiomas are the most commonly reported radiation-induced neoplasms reported in the literature and there is some suggestion of increasing incidence due to the expanding indications for radiation therapy and increasing longevity of patients after radiation therapy. 5,7 The risk of developing a meningioma in post-radiation patients is described as 6-10× higher than the standard population.…”

Section: Introductionmentioning

confidence: 99%

Secondary malignancy following radiotherapy for thyroid eye disease

Gillis

Chang

Al-Kharazi

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Thyroid eye diseaseRadiotherapy Meningioma a b s t r a c t Aim: To describe the first case of a secondary meningioma in a patient after radiation treatment for thyroid eye disease (TED). Secondarily to identify any additional cases of secondary malignancy resulting from radiotherapy for thyroid eye disease from our institutional experience.Background: Thyroid eye disease (TED) is a self-limiting auto-immune disorder causing expansion of orbital soft tissue from deposition of glycosaminoglycans and collagen, leading to significant cosmetic and functional morbidity. Established management options for TED include: glucocorticosteroids, orbital radiotherapy, and surgical orbital decompression.Two large series on radiotherapy for TED have been reported without any cases of secondary malignancy. Materials and methods:The case of a patient with visual failure, found to have a sphenoid wing meningioma after previous TED radiotherapy is described. We then reviewed 575 patients with at least 3-year follow-up receiving radiotherapy for TED at British Columbia Cancer Agency to identify other possible secondary malignancies. Results:The patient had postoperative improvement in her vision without any identified complications. Three additional cases of hematologic malignancy were identified. The calculated risk in our population of developing a radiation-induced meningioma after TED with at least 3 years of follow-up of is 0.17% (1/575); with hematopoetic malignancies the risk for secondary malignancy is 0.7% (4/575).reports of practical oncology and radiotherapy 2 1 ( 2 0 1 6 ) 156-161 157 Conclusions: Our calculated risk for secondary malignancy (0.17%, 0.7%) is similar to the reported theoretical risk published in the literature (0.3-1.2%). There is real risk for the development of a secondary malignancy after radiotherapy treatment of TED and treatment options should include consideration for this potential.

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“…4) (Kunert et al 2012;Mansouri et al 2014;Madden et al 2010). In the study of Kunert et al, 2 % of meningiomas were associated with previous radiation treatment (c) Contrast-enhanced imaging confirms the classical appearance of meningiomas; the frontal lesion was histologically confirmed (Kunert et al 2012). The average time after initial treatment was 24 years, and some of the patients developed multiple tumors which was described as a common feature by Mansouri et al (2014) and is also found in our presented case.…”

Section: Imaging Findings After Radiation Of the Brainmentioning

confidence: 99%

“…Although rare, the most common induced tumors are meningiomas (Fig. 4) (Kunert et al 2012;Mansouri et al 2014;Madden et al 2010). In the study of Kunert et al, 2 % of meningiomas were associated with previous radiation treatment (c) Contrast-enhanced imaging confirms the classical appearance of meningiomas; the frontal lesion was histologically confirmed (Kunert et al 2012).…”

Section: Imaging Findings After Radiation Of the Brainmentioning

confidence: 99%