Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytes

Dreizen, Samuel; Brown, Lee R.; Handler, Sandra; Levy, Barnet M.

doi:10.1002/1097-0142(197607)38:1<273::aid-cncr2820380141>3.0.co;2-8

Cited by 210 publications

(61 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Xerostomia can result in long-term or even permanent oral function impairment and usually is associated with morbidity that profoundly affects the quality of life. [1][2][3][4] Several potential methods for preventing radiation-induced xerostomia have been described; however, xerostomia management is complex and often is refractory to most interventions. 5 Studies using systemic sialogogues (e.g., pilocarpine) concomitant with RT have failed to show significant maintenance of saliva production.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer

et al. 2011

View full text Add to dashboard Cite

The aim of this study was to evaluate the effectiveness of acupuncture in minimizing the severity of radiation-induced xerostomia in patients with head and neck cancer. A total of 24 consecutive patients receiving > 5000 cGy radiotherapy (RT) involving the major salivary glands bilaterally were assigned to either the preventive acupuncture group (PA, n = 12), treated with acupuncture before and during RT, or the control group (CT, n = 12), treated with RT and not receiving acupuncture. After RT completion, clinical response was assessed in all patients by syalometry, measuring the resting (RSFR) and stimulated (SSFR) salivary flow rates, and by the visual analogue scale (VAS) regarding dry mouth-related symptoms. Statistical analyses were performed with repeated-measures using a mixed-effect modeling procedure and analysis of variance. An alpha level of 0.05 was accepted for statistical significance. Although all patients exhibited some degree of impairment in salivary gland functioning after RT, significant differences were found between the groups. Patients in the PA group showed improved salivary flow rates (RSFR, SSFR; p < 0.001) and decreased xerostomia-related symptoms (VAS, p < 0.05) compared with patients in the CT group. Although PA treatment did not prevent the oral sequelae of RT completely, it significantly minimized the severity of radiation-induced xerostomia. The results suggest that acupuncture focused in a preventive approach can be a useful therapy in the management of patients with head and neck cancer undergoing RT.

show abstract

Section: Introductionmentioning

confidence: 99%

Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…36,37 Using a rat model in this study, we showed that HSP25 and HSP70i protected radiation-induced submandibular damage and that this protective effect was attributable to inhibition of cell death and restoration of saliva fluid.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective Effect of Heat Shock Protein 25 on Submandibular Glands of Rats

Lee

Kwon

et al. 2006

The American Journal of Pathology

View full text Add to dashboard Cite

Irradiation (IR) is a fundamental treatment modality for head and neck malignancies. However, a significant drawback of IR treatment is irreversible damage of salivary gland in the IR field. In the present study, we investigated whether heat shock protein (HSP) 25 could be used as a radioprotective molecule for radiation-induced salivary gland damage in rats. HSP25 as well as inducible HSP70 (HSP70i) that were delivered to the salivary gland via an adenoviral vector significantly ameliorated radiation-induced salivary fluid loss. Radiation-induced apoptosis, caspase-3 activation, and poly(ADP-ribose) polymerase cleavage in acinar cells, granular convoluted cells, and intercalated ductal cells were also inhibited by HSP25 or HSP70i transfer. The alteration of salivary contents, including amylase, protein, Ca ؉ , Cl ؊ , and Na ؉ , was also attenuated by HSP25 transfer. Histological analysis revealed almost no radiation-induced damage in salivary gland when HSP25 was transferred. Aquaporin 5 expression in salivary gland was inhibited by radiation; and HSP25 transfer to salivary gland prevented this alteration. The protective effect of HSP70i on radiationinduced salivary gland damage was less or delayed than that of HSP25. These results indicate that HSP25 is a good candidate molecule to protect salivary gland from the toxicity

show abstract

“…b Entwicklungsstö-rungen der Zähne nach Bestrahlung. Frontzähne überkront, Restbezahnung hypoplastisch und kariesanfällig eine geringe Speichelflussrate generell mit einem erhöhten Kariesrisiko assoziiert ist [2,12]. Diese Beobachtungen unterstützen die These, welche die Hyposalivation mitsamt ihren Folgen als Ursache für die rasche Zerstörung der Zähne bei bestrahlten Patienten sieht.…”

Section: Speichelflussunclassified