Radiation injury in surgical pathology

Fajardo, Luis F.; Berthrong, M

doi:10.1097/00000478-197806000-00005

Cited by 185 publications

(34 citation statements)

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“…In almost half the cases in which massive hemoptysis occurred, underlying cavitation was present. This figure was in striking contrast ( P < 0.0001) to that for cases with submassive hemoptysis, without hemoptysis, and for the total series, in which cavitation was a relatively unusual occurrence (10.776, 4.076, and 6.576, respectively).…”

Section: Resultscontrasting

confidence: 56%

Hemorrhage from carcinoma of the lung

Miller

McGregor

1980

Cancer

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During a retrospective analysis of 877 cases of lung cancer, we explored the relationships between cell type, site, cavitation, varying degrees of hemoptysis, and radiation therapy. Massive terminal hemoptysis (29 cases) was found to be significantly associated with cavitated (P less than 0.0001 squamous cell carcinoma (P = 0.0002), ARISING IN EITHER THE RIGHT OR LEFT MAIN BRONCHI (P less than 0.0001). Lesser, nonlethal degrees of hemoptysis (140 cases) were not cell-type associated, occurring in approximately 15% of cases of all major tumor types. Radiotherapy, although employed more frequently in the massive-hemoptysis population, did not appear to be causally related to hemoptysis of any degree. An interesting case, which provoked the above study, is described: a patient with bronchogenic squamous cell carcinoma and terminal hemoptysis due to a tumor fistula between the primary lesion and the left atrial chamber. The forms of cardiac involvement in lung cancer are discussed.

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Section: Resultscontrasting

confidence: 56%

Hemorrhage from carcinoma of the lung

Miller

McGregor

1980

Cancer

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“…The precise role of the fibroblasts in development of postradiation fibrosis has not been determined. Several investigators have reported the presence of large fibroblasts, characterized by multiple cytoplasmic projections and irregular nuclei, in irradiated tissue ( 140). Although these cells are not specific for radiation injury, they have often been named 'radiation fibroblasts'.…”

Section: Intestinal Wall Jibrosismentioning

confidence: 99%

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Hauer‐Jensen

1990

Acta Oncologica

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“…It has a biphasic nature with the acute effects occurring over days to weeks and a delayed response, which can occur from months to years after completion of the therapy [18]. The acute phase usually involves acute inflammatory changes which may lead to desquamation or even necrosis of tissue [19].…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy and breast reconstruction: a meta-analysis

Barry

Kell

2011

Breast Cancer Res Treat

237

126

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To cite this version:M Barry, M. R. Kell. Radiotherapy and breast reconstruction: a meta-analysis. Breast Cancer Research and Treatment, Springer Verlag, 2011, 127 (1) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured.. Results:1,105 patients were identified from 11 appropriately selected studies.Patients undergoing PMRT and BR are more likely to suffer morbidity compared to patients not receiving PMRT ((OR) = 4.2; 95% CI, 2.4-7.2(no PMRT vs. PMRT)). Reconstruction technique was also examined with outcome whenPMRT was delivered after BR and this demonstrated that autologous reconstruction is associated with less morbidity in this setting ((OR) = 0.21; (95% CI, 0.1-0.4 (autologous vs. implant based)). Delaying BR until after PMRT had no significant effect on outcome ((OR) =0.87; 95% CI, 0.47-1.62 (delayed vs. immediate)).Conclusions: PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared to implant based reconstruction. 3 INTRODUCTION:Breast Eligibility CriteriaAll trials whether randomized or non-randomized, prospective or retrospective were eligible that examined the effects of radiotherapy on immediate or delayed breast reconstruction using either a prosthesis or autologous tissue (Latissimus Dorsi (LD) or Trasversus Rectus Abdominis Muscle (TRAM). Case series orreports were not included. Studies where the data could not be accurately extracted were also excluded. Data Extraction and OutcomesThe following information regarding each eligible trial was recorded: authors' names, journal, patient numbers, timing and method of reconstruction, addition of radiotherapy and the post-operative complication rate. The primary end point of 7 this meta-analysis was postoperative morbidity including capsular contracture, fibrosis, fat necrosis, surgical site infections requiring removal of prosthesis/reoperation (see tables 2, 4 and 6). Statistical AnalysisFor post-operative complications in each study, the odds ratio (O.R.) of the simple proportions of events was estimated with its variance and 95% CI.Heterogeneity between the O.R.s for the same outcome between studies was assessed by use of the X 2 -based Q statistic [24]. Data were then combined across studies by the use of general variance methods with fixed and random effects models [14]. Analyses were conducted using StatsDirect version 2.5.6(StatsDirect Ltd, Chesire, United Kingdom) and SPSS version 12.0 (SPSS, Inc, Chicago, IL). All statistical tests were two tailed. 8 RESULTS:Eligible Studies 20 potentially eligible studies were identified that examined the effects of radiotherapy on immediate or delayed breast reconstructions. 9 studies were excluded from the meta-analysis due to low numbers (e.g. n < 15) or incomplete data set regarding postoperative morbidity. Of the 11 studies selected, 4 were studies that examined the effects of RT...

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Radiation injury in surgical pathology

Cited by 185 publications

References 0 publications

Hemorrhage from carcinoma of the lung

Hemorrhage from carcinoma of the lung

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Radiotherapy and breast reconstruction: a meta-analysis

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