Radiation injury in the human kidney: A prospective analysis using specific scintigraphic and biochemical endpoints

Re-Treatment After Full-Course Radiotherapy: Is It a Viable Option?

“…This is entirely consistent with clinical observations of slowly progressive renal damage that can occur over periods of 5 to 10 years after irradiation (41,42). Based on the known profiles for development of renal damage, it is obvious that re-irradiation after large initial doses is unlikely to be feasible.…”

Treatment of abdominal tumors using radiotherapy

“…47,53 The main complication reported when there is an excess dose is decrease in renal function when the kidney's dose is greater than its tolerance (B). 54 Assessments of the dose received by irradiated organ volume show the tolerance thresholds below which there is no toxicity (B) [55][56][57][58][59][60][61] (D).…”

Locally advanced rectal cancer with a pelvic kidney complicating adjuvant radiation therapy

“…Renal irradiation to 23 Gy over a 5-week period is associated with a 5% risk of renal failure at 5 years; the rate increases to 50% after 28 Gy [6]. Dewit et al [7] showed a 3040% decrease in renal function, as assessed by scintigraphy after 3-5 years of administration of 40 Gy in 54 weeks. Radiation nephropathy is a slowly progressive, noninflammatory disease with a wide clinical and histological spectrum, depending on total dose, fractionation schedule, age of the patient, and comorbid factors.…”