Radiation proctitis: predictors of mortality and inpatient outcomes in the United States

Dahiya, Dushyant Singh

doi:10.20524/aog.2021.0684

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As per the literature from Dahiya (17) , older patients (mean age 72.3 ± 0.5 years) have been shown to be prone to hospitalizations due to radiation proctitis. Our study also indicated that older patients (≥ 54 years old) had a greater risk of hemorrhagic CRP.…”

Section: Discussionmentioning

confidence: 73%

High-risk factors and predictive models for hemorrhagic chronic radiation proctitis

Liao,

Hu,

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Hemorrhagic chronic radiation proctitis (CRP) is the most common and stubborn complication after pelvic radiation therapy. Understanding the high-risk factors, exploring a method to predict it, and then formulating a reasonable radiotherapy plan are the keys to preventing hemorrhagic CRP. The aim of this study was to retrospectively identify potential risk factors for hemorrhagic CRP and establish a nomogram to predict the onset of hemorrhagic CRP. Methods In this retrospective study, we considered patients who received pelvic radiotherapy for cervical carcinoma from March 2014 to December 2021 at Chongqing University Cancer Hospital (Chongqing, China). Logistic regression analysis was performed to determine the factors and then a nomogram model was established. To evaluate the performance of the model, metrics such as the area under the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis were used. Results A total of 221 patients were included.125 patients diagnosed with hemorrhagic CRP by colonoscopy. The median time of diagnosis of hemorrhagic CRP was 14.45 months after pelvic radiotherapy. Age (≥ 54 years old), weight (< 52 kg) and total radiation dose (≥ 72 Gy) were identified as risk factors and then a nomogram was established to predict the onset of hemorrhagic CRP. The area under the ROC curve (AUC) values of the nomogram were 0.741 and 0.74 in the training and the validation cohort, respectively. To investigate the clinical utility of the model,decision curves and clinical impact curves were further performed. The results showed that the model was beneficial over a wide probability range from 0.25 to 0.85. and 0.74 in the training and the validation set, respectively. Conclusion In this study, we constructed and developed a nomogram for hemorrhagic CRP. The calibration curves, ROC curve analysis, and decision curves showed that the nomogram was reliable for clinical application. It may provide some evidence for radiologist to make a reasonable radiotherapy plan to preventing hemorrhagic CRP. Trial registration retrospectively registered.

show abstract

Section: Discussionmentioning

confidence: 73%

High-risk factors and predictive models for hemorrhagic chronic radiation proctitis

Liao,

Hu,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Preventive efficacy of hydrocortisone enema for radiation proctitis in rectal cancer patients undergoing short-course radiotherapy: a phase II randomized placebo-controlled clinical trial

Mohammadianpanah,

Tazang,

Nguyen

et al. 2024

Ann Coloproctol

View full text Add to dashboard Cite

Purpose: This study aimed to investigate the efficacy of hydrocortisone enema in preventing radiation proctitis in patients with rectal cancer undergoing short-course radiotherapy (SCRT).Methods: This phase II randomized controlled trial enrolled patients with newly diagnosed locally advanced rectal cancer (clinically staged T3–4 and/or N1–2M0). Participants received a median of 4 cycles of neoadjuvant chemotherapy (capecitabine plus oxaliplatin) followed by 3-dimensional conformal SCRT (25 Gy in 5 fractions). Patients were randomly assigned to receive either a hydrocortisone enema (n=50) or a placebo (n=51) once daily for 5 consecutive days during SCRT. The primary endpoint was the incidence and severity of acute proctitis.Results: Of the 111 eligible patients, 101 were included in the study. Baseline characteristics, including sex, age, performance status, and tumor location, were comparable across the treatment arms. None of the patients experienced grade 4 acute gastrointestinal toxicity or had to discontinue treatment due to treatment-related adverse effects. Patients in the hydrocortisone arm experienced significantly less severe proctitis (P<0.001), diarrhea (P=0.023), and rectal pain (P<0.001) than those in the placebo arm. Additionally, the duration of acute gastrointestinal toxicity following SCRT was significantly shorter in patients receiving hydrocortisone (P<0.001).Conclusion: Hydrocortisone enema was associated with a significant reduction in the severity of proctitis, diarrhea, and rectal pain compared to placebo. Additionally, patients treated with hydrocortisone experienced shorter durations of gastrointestinal toxicity following SCRT. This study highlights the potential benefits of hydrocortisone enema in managing radiation-induced toxicity in rectal cancer patients undergoing radiotherapy.

show abstract

Radiation proctitis: predictors of mortality and inpatient outcomes in the United States

Cited by 2 publications

References 13 publications

High-risk factors and predictive models for hemorrhagic chronic radiation proctitis

High-risk factors and predictive models for hemorrhagic chronic radiation proctitis

Preventive efficacy of hydrocortisone enema for radiation proctitis in rectal cancer patients undergoing short-course radiotherapy: a phase II randomized placebo-controlled clinical trial

Contact Info

Product

Resources

About