Radiation recall dermatitis with pemetrexed

Unsuccessful rechallenge with pemetrexed after a previous radiation recall dermatitis

“…In fact, one case of radiation recall dermatitis following pemetrexed infusion in a patient with mesothelioma treated with radiation therapy to the drainage orifices has been previously reported [3]. In this case, however, the waiting period between the end of radiation therapy and pemetrexed infusion was of less than 3 weeks.…”

Chemotherapeutic agents and the skin: An update

“…Twelve days later, pruritic confluent erythema developed. 253 This is an important side effect to be aware of, because radiation therapy often accompanies chemotherapy in the treatment of mesothelioma. The second case developed in a patient who had been treated with radiation therapy for breast cancer 27 years earlier.…”

Radiation Recall with Vinorelbine and Cisplatin

“…To our knowledge, there have been no reports on radiation recallinducedbythesoleuseofeithervinorelbineorcisplatin sofar.However,wecouldnotruleoutthefactthatthisreactionmaybeobservedinpractice.Somepreviousstudieshave reported on RRD induced by a combinatorial treatment including one of these two agents. Castellano et al reported thatapatientdevelopedRRDandradiationrecallpneumonitis after combined use of vinorelbine and gemcitabine [13], and Hureaux et al reported on another case of RRD in response to the combination of cisplatin and pemetrexed [14]. Fromthecurrentsinglecase,wecannotconcludewhichagent was responsible for the radiation recall, or whether it was caused by the combination of agents.…”