Radiation-related Quality of Life Parameters after Targeted Intraoperative Radiotherapy vs. Whole Breast Radiotherapy in Patients with Breast Cancer: Results from the Randomized Phase III Trial TARGIT-A

Welzel, Grit; Boch, A.; Blank, E.; Kraus-Tiefenbacher, U.; Keller, Anke; Hermann, Brigitte; Sütterlin, Marc; Wenz, Frederik

doi:10.1016/j.ijrobp.2011.06.376

Cited by 4 publications

(1 citation statement)

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“…Higher frequency of postoperative wound seroma was found after IORT in Vinh-Hung study, in accordance with the evidences of TARGIT-A, however it was not significantly associated with the rate of fibrosis, that was observed to be higher in the IORT boost group together with toxicity grade 3/4. The minor rate of fibrosis in the IORT group can be correlated to the evidences of less breast and arm symptoms ( 19 ).…”

Section: Radiation Toxicitymentioning

confidence: 96%

Is current clinical practice modified about intraoperative breast irradiation?

Massa

Franchelli

Panizza

et al. 2016

Chinese Journal of Cancer Research

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After the results obtained in the two randomized clinical trial, the ELIOT trial and the TARGIT-A trial, a heated debate is going on concerning the question of applying intraoperative radiotherapy (IORT) instead of postoperative whole breast irradiation (WBI) after breast conservative treatment. Currently, many centers are applying the IORT following the strict selection criteria dictated by the working groups American Society for Radiation Oncology (ASTRO) and Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) and monitoring the oncological outcome together with radiation toxicity on breast tissue. The clinical experience of the Geneva University Hospital regarding the use of the Intrabeam system is evaluated and compared with current evidences.

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Section: Radiation Toxicitymentioning

confidence: 96%

Is current clinical practice modified about intraoperative breast irradiation?

Massa

Franchelli

Panizza

et al. 2016

Chinese Journal of Cancer Research

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Partial breast irradiation for early breast cancer

Hickey

Lehman

Francis

et al. 2016

Cochrane Database of Systematic Reviews

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It appeared that local recurrence and 'elsewhere primaries' (new primaries in the ipsilateral breast) are increased with PBI/APBI (the difference was small), but we found no evidence of detriment to other oncological outcomes. It appeared that cosmetic outcomes and some late effects were worse with PBI/APBI but its use was associated with less acute skin toxicity. The limitations of the data currently available mean that we cannot make definitive conclusions about the efficacy and safety or ways to deliver of PBI/APBI. We await completion of ongoing trials.

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