Radiation responses of stem cells: targeted and non-targeted effects

Kavanagh, Joy N.; Waring, E. J.; Prise, Kevin M.

doi:10.1093/rpd/ncv161

Cited by 3 publications

(3 citation statements)

References 80 publications

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“…When implemented, this will facilitate multidisciplinary research that integrates key aspects of radiation oncology ( 114 ), epidemiology ( 115 , 116 ), physics ( 117 ), and survivorship ( 118 , 119 ). In addition, this may be relevant to some radiobiologic research, such as abscopal ( 120 ) and other non-targeted effects (e.g., radiation-induced bystander effect, genomic instability, and the radiation response of stem cells) ( 121 ) and modulation of radiation response (e.g., radiosensitizers and radioprotectors) and novel combination therapies ( 122 ). The American Association of Physicists in Medicine pointed out potential dangers of using biological models for clinical radiotherapy and provided guidelines and methodology for quality assurance ( 123 ).…”

Section: Discussionmentioning

confidence: 99%

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

et al. 2016

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The number of incident cancers and long-term cancer survivors is expected to increase substantially for at least a decade. Advanced technology radiotherapies, e.g., using beams of protons and photons, offer dosimetric advantages that theoretically yield better outcomes. In general, evidence from controlled clinical trials and epidemiology studies are lacking. To conduct these studies, new research methods and infrastructure will be needed. In the paper, we review several key research methods of relevance to late effects after advanced technology proton-beam and photon-beam radiotherapies. In particular, we focus on the determination of exposures to therapeutic and stray radiation and related uncertainties, with discussion of recent advances in exposure calculation methods, uncertainties, in silico studies, computing infrastructure, electronic medical records, and risk visualization. We identify six key areas of methodology and infrastructure that will be needed to conduct future outcome studies of radiation late effects.

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Section: Discussionmentioning

confidence: 99%

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

et al. 2016

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“…Radiation causes ultrastructural and biochemical changes in hepatocytes, which are known to depend on lipid metabolism[ 28 ]. Radiation exposure is one of the causes of hepatic fibrosis after liver injury recovery[ 29 - 31 ]. However, there is no particular information on the role of K ATP channel subunits in radiation-induced liver damage.…”

Section: Introductionmentioning

confidence: 99%

Expression levels of K_ATP channel subunits and morphological changes in the mouse liver after exposure to radiation

Zhou,

Li,

Abe

et al. 2024

World J Exp Med

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BACKGROUND ATP sensitive K+ (KATP) channels are ubiquitously distributed in various of cells and tissues, including the liver. They play a role in the pathogenesis of myocardial and liver ischemia. AIM To evaluate the radiation-induced changes in the expression of KATP channel subunits in the mouse liver to understand the potential role of KATP channels in radiation injury. METHODS Adult C57BL/6 mice were randomly exposed to γ-rays at 0 Gy (control, n = 3), 0.2 Gy (n = 6), 1 Gy (n = 6), or 5 Gy (n = 6). The livers were removed 3 and 24 h after radiation exposure. Hematoxylin and eosin staining was used for morphological observation; immunohistochemical staining was applied to determine the expression of KATP channel subunits in the liver tissue. RESULTS Compared with the control group, the livers exposed to 0.2 Gy γ-ray showed an initial increase in the expression of Kir6.1 at 3 h, followed by recovery at 24 h after exposure. Exposure to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 h. However, the expression of Kir6.2, SUR1, or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these doses. CONCLUSION The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses, suggesting a potential role for them in radiation-induced liver injury.

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“…Radiation exposures are generally classified as high (above 5 Gy), moderate (0.5~5 Gy) and low doses (below 0.5 Gy)1. Epidemiological studies on the atomic bomb survivors of Hiroshima and Nagasaki23, workers from the Mayak nuclear facility in the Russian Federation456, and the Chernobyl liquidators7 have clearly suggested that high dose ionizing radiation increase the cardiovascular disease (CVD) risk89.…”

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confidence: 99%

Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice

Luo

Yan

Urata

et al. 2017

Sci Rep

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We evaluated the dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells (CDCs), a mixed cell population grown from heart tissues. Adult C57BL/6 mice were exposed to 0, 10, 50 and 250 mGy γ-rays for 7 days and atrial tissues were collected for experiments 24 hours after last exposure. The number of CDCs was significantly decreased by daily exposure to over 250 mGy. Interestingly, daily exposure to over 50 mGy significantly decreased the c-kit expression and telomerase activity, increased 53BP1 foci in the nuclei of CDCs. However, CD90 expression and growth factors production in CDCs were not significantly changed even after daily exposure to 250 mGy. We further evaluated the reversibility of radiation-induced injury in CDCs at 1 week and 3 weeks after a single exposure to 3 Gy γ-rays. The number and growth factors production of CDCs were soon recovered at 1 week. However, the increased expression of CD90 were retained at 1 week, but recovered at 3 weeks. Moreover, the decreased expression of c-kit, impaired telomerase activity, and increased 53BP1 foci were poorly recovered even at 3 weeks. These data may help us to find the most sensitive and reliable bio-parameter(s) for evaluating radiation-induced injury in CDCs.

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Radiation responses of stem cells: targeted and non-targeted effects

Cited by 3 publications

References 80 publications

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

Expression levels of K_ATP channel subunits and morphological changes in the mouse liver after exposure to radiation

Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice

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Radiation responses of stem cells: targeted and non-targeted effects

Cited by 3 publications

References 80 publications

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

Expression levels of KATP channel subunits and morphological changes in the mouse liver after exposure to radiation

Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice

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Expression levels of K_ATP channel subunits and morphological changes in the mouse liver after exposure to radiation