Background: Invasive cardiac procedures expose patients and physicians to ionising radiation. The aim of this study was to determine the impact of body weight on radiation exposure during cardiac procedures. Methods: A prospective cohort study of patients undergoing cardiac catheterisation or percutaneous coronary intervention (PCI) between August of 2010 and December of 2011. Clinical, angiographic, and radiation exposure characteristics were recorded in a dedicated database. Radiation exposure patterns were established in three groups: A (≤ 79 kg), B (80-99 kg), and C (≥ 100 kg). Data were analysed using the Statistical Package for Social Sciences (SPSS), version 18.0, and the results were presented as the mean, standard deviation, percentage, percentile, and interquartile interval. The independent predictors of increased radiation exposure were identified using a multiple logistic regression analysis. Results: The sample included a total of 671 patients, 363 in group A, 252 in group B, and 56 in group C. The mean dose of radiation exposure was 484.29 mGy, 735.69 mGy, and 900.36 mGy for groups A, B, and C, respectively (P < 0.001). The median dose area product was 29.327 mGy.cm², 43.319 mGy.cm², and 57.987 mGy.cm² for groups A, B, and C, respectively (P < 0.001). The predictors of increased radiation exposure were weight (odds ratio [OR] 1.03, confidence interval [CI] 1.01-1.05, P = 0.003), confidence interval (CI) 1.01-1.05, P = 0.003], elective PCI (OR 11.9, CI 4.26-33.24, P < 0.001), and ad hoc PCI (OR 15.46,.87, P < 0.001). Conclusions: Patient weight has a significant impact on radiation exposure during invasive cardiac procedures. Overweight patients are significantly more exposed to higher doses of ionising radiation.