Radiation Sensitivity of Human Histiocytic Lymphomas in Vitro

Johansson, Leif; Carlsson, Jörgen; Nilsson, Kenneth

doi:10.3109/02841868309134047

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The Mitotic Delay1

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1985

1999

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Cited by 5 publications

(2 citation statements)

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“…Because of these disadvantages, previous workers have developed the growth extrapolation method to study the radiation sensitivity of leukaemidymphoma cell lines (3,4). Although this alternative method is comparable to the colony formation method, it is cumbersome and requires correction for mitotic delay (9).…”

Section: Discussionmentioning

confidence: 99%

Radiation Sensitivity of Human Malignant Lymphocytes

Seshadri

Matthews

Morley

1985

Acta Radiologica: Oncology

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Section: Discussionmentioning

confidence: 99%

Radiation Sensitivity of Human Malignant Lymphocytes

Seshadri

Matthews

Morley

1985

Acta Radiologica: Oncology

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“…For simplicity this factor, called m, was here set to 1.5 hr/Gy in all calculations. This approximation was based on earlier data for human tumour cells [27].…”

Section: The Mitotic Delaymentioning

confidence: 99%

The doubling time of human tumours during radiotherapy: An analysis based on comparison between clinical and in vitro tumour cell radioresponsiveness

Brodin

1994

Radation Oncology Invest

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SUMMARY A correspondence between the effect of 2 Gy in vitro for human tumour cell lines and the clinical effect of radiotherapy of the corresponding tumours has earlier been described. In this analysis data on surviving fraction (SF) in vitro have been applied to clinical studies in a predictive model similar to the linear-quadratic model for the calculation of isodoses. In addition, a proliferation factor describing exponential growth has been included. Different proliferation rates have been tested and the predicted probabilities for local control have been compared with the clinical local control rates of respective studies. The best correspondence between predicted and clinical results were found for a potential doubling time of 2-3 days during a whole treatment course, even for radiotherapy courses shorter than 3 4 weeks. The possible impact of hypoxia is discussed. Radiat Oncol Invest 1994;2:99-108.

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