Radiation Sensitivity of the Human Testis

Meistrich, Marvin L.; Beek, M. E. A. B. van

doi:10.1016/b978-0-12-035414-6.50012-2

Cited by 78 publications

(51 citation statements)

References 92 publications

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“…The cell of origin has not been identified but is presumed to be an early cell in the spermatogenesis pathway (Peckham, 1981). It would be a remarkable coincidence if the efficacy of both radiation and chemotherapy in this cancer were not associated with the high sensitivity of normal male germ cells to DNA-damaging agents (Meistrich & Van Beel, 1990), an unusual feature they share with lymphocyte progenitor cells. …”

Section: Non-hodgkin'sfollicular Tymphomamentioning

confidence: 99%

Stem cell origins of leukaemia and curability

1993

Br J Cancer

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It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.

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Section: Non-hodgkin'sfollicular Tymphomamentioning

confidence: 99%

Stem cell origins of leukaemia and curability

1993

Br J Cancer

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“…Doses of greater than 20 cGy are required to produce azoospermia. (Meistrich & van Beek, 1990). Spermatogonia are most radiosensitive, spermatocytes are damaged at doses of 200-300 cGy and spermatids at 400-600 cGy (Rowley et al, 1974).…”

Section: Irradiationmentioning

confidence: 99%

“…After single dose exposure, complete recovery occurs at 9-18 months after less than 100 cGy, 30 months after 200-300 cGy and 5 or more years after 400-600 cGy (Shalet, 1983). The recovery is longer after fractionated doses (Hahn et al, 1982;Meistrich & van Beek, 1990). The effects of radiation on human DNA is not entirely clear.…”

Section: Irradiationmentioning

confidence: 99%

“…Radiation effects on the testis have been described in men receiving treatment for seminoma (Hahn et al, 1982) and inverted Y irradiation for Hodgkin's disease (Shalet, 1983). There is also scatter of irradiation from other radiotherapeutic procedures in the vicinity of the testis and shielding is therefore important (Meistrich & van Beek, 1990). Radioiodine therapy for thyroid cancer has been associated with dose-dependent spermatogenic damage, appearing at threshold doses greater than 100 mCi.…”

Section: Irradiationmentioning

confidence: 99%

“…(Handelsman & Turtle, 1983). The effects of occupational exposure to irradiation at levels up to 3 cGy/year are not well documented, but are likely to be subtle (Meistrich & van Beek, 1990).…”

Section: Irradiationmentioning

confidence: 99%

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Gonadal function in men with chronic illness

Turner

Wass

1997

Clinical Endocrinology

104

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Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for ewing and soft tissue sarcomas

Meistrich¹,

Wilson²,

Brown

et al. 1992

Cancer

233

107

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Background. Treatment of cancer with multiple‐drug chemotherapy regimens or radiation therapy can cause either temporary azoospermia of various durations or permanent azoospermia in young men. Methods. To identify which drugs in which doses contribute to long‐term or permanent azoospermia, semen analyses were done on patients with Ewing and soft tissue sarcomas before, during, and after treatment with either CYADIC (cyclophosphamide, doxorubicin, and dacarbazine), or CYVADIC (vincristine added to CYADIC). Some patients also received other drugs or radiation therapy. Results. From pretreatment levels that were similar to those of control subjects, sperm production declined to azoospermia within 4 months of treatment. Sperm production returned in some patients after treatment; 40% of men recovered to normospermic levels by 5 years after treatment. Few patients showed continued recovery of sperm production after that time. The cumulative dose of cyclophosphamide was the most significant determinant of recovery to normospermic levels; approximately 70% of those who had received doses less than 7.5 g/m2 (median, 4.1 g/m2) recovered, but only 10% recovered when doses exceeded 7.5 g/m2. Conclusions. Thus, a risk of permanent sterility is associated with the use of the CYADIC and CYVADIC regimens in young men, especially when the cumulative dose of cyclophosphamide is greater than 7.5 mg/m2.

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Radiation Sensitivity of the Human Testis

Cited by 78 publications

References 92 publications

Stem cell origins of leukaemia and curability

Stem cell origins of leukaemia and curability

Gonadal function in men with chronic illness

Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for ewing and soft tissue sarcomas

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