Radiation Sensitivity of the Liver: Models and Clinical Data

Naqa, Issam El; Cuneo, Kyle C.; Owen, Dawn; Lawrence, Theodore S.; Haken, R.K. Ten

doi:10.1007/978-3-319-54531-8_4

Cited by 3 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Radiationinduced liver toxicity is a major factor in RT regime design. 207 A unique aspect of the liver is its two-phase perfusion model, arterial phase, and portal phase. While liver is considered as a single compartment, it receives blood inflows from the hepatic artery and portal vein.…”

Section: Othersmentioning

confidence: 99%

See 1 more Smart Citation

Multi‐parametric MRI (mpMRI) for treatment response assessment of radiation therapy

Wang

Padgett

et al. 2021

Medical Physics

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) plays an important role in the modern radiation therapy (RT) workflow. In comparison with computed tomography (CT) imaging, which is the dominant imaging modality in RT, MRI possesses excellent soft‐tissue contrast for radiographic evaluation. Based on quantitative models, MRI can be used to assess tissue functional and physiological information. With the developments of scanner design, acquisition strategy, advanced data analysis, and modeling, multiparametric MRI (mpMRI), a combination of morphologic and functional imaging modalities, has been increasingly adopted for disease detection, localization, and characterization. Integration of mpMRI techniques into RT enriches the opportunities to individualize RT. In particular, RT response assessment using mpMRI allows for accurate characterization of both tissue anatomical and biochemical changes to support decision‐making in monotherapy of radiation treatment and/or systematic cancer management. In recent years, accumulating evidence have, indeed, demonstrated the potentials of mpMRI in RT response assessment regarding patient stratification, trial benchmarking, early treatment intervention, and outcome modeling. Clinical application of mpMRI for treatment response assessment in routine radiation oncology workflow, however, is more complex than implementing an additional imaging protocol; mpMRI requires additional focus on optimal study design, practice standardization, and unified statistical reporting strategy to realize its full potential in the context of RT. In this article, the mpMRI theories, including image mechanism, protocol design, and data analysis, will be reviewed with a focus on the radiation oncology field. Representative works will be discussed to demonstrate how mpMRI can be used for RT response assessment. Additionally, issues and limits of current works, as well as challenges and potential future research directions, will also be discussed.

show abstract

Section: Othersmentioning

confidence: 99%

“…Liver is another common site for RT. Radiation‐induced liver toxicity is a major factor in RT regime design 207 . A unique aspect of the liver is its two‐phase perfusion model, arterial phase, and portal phase.…”

Section: Mpmri In Rt Treatment Response Assessmentmentioning

confidence: 99%

Multi‐parametric MRI (mpMRI) for treatment response assessment of radiation therapy

Wang

Padgett

et al. 2021

Medical Physics

View full text Add to dashboard Cite

show abstract

“…These include using SPECT with asialoglycoprotein receptor (ASGPR) [28], iminodiacetic acid (IDA) [29] or albumin [30] Technetium-99m tagged tracers. However, the incorporation of such valuable imaging information into NTCP modeling of the liver remains limited with the focus being on dose-volume modeling [31].…”

Section: Introductionmentioning

confidence: 99%