Radiation signatures in childhood thyroid cancers after the Chernobyl accident: Possible roles of radiation in carcinogenesis

Suzuki, Keiji; Mitsutake, Norisato; Saenko, Vladimir; Yamashita, Shunichi

doi:10.1111/cas.12583

Cited by 27 publications

(20 citation statements)

References 72 publications

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“…Furthermore, this signature allows for classifying tumors from Belarus and Ukraine as either sporadic or occurring in highly contaminated subjects during the Chernobyl accident (43). These data confirm previous studies (44)(45)(46)(47) and suggest that radiation-induced tumors may have some specific molecular characteristics, but this should be confirmed on a larger series of tumors.…”

Section: Radiation-induced Thyroid Cancersupporting

confidence: 85%

Radiation exposure and thyroid cancer: a review

Iglesias

Schmidt

Ghuzlan

et al. 2017

Arch. Endocrinol. Metab.

163

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The association between radiation exposure and the occurrence of thyroid cancer has been well documented, and the two main risk factors for the development of a thyroid cancer are the radiation dose delivered to the thyroid gland and the age at exposure. The risk increases after exposure to a mean dose of more than 0.05-0.1 Gy (50-100mGy). The risk is more important during childhood and decreases with increased age at exposure, being low in adults. After exposure, the minimum latency period before the appearance of thyroid cancers is 5 to 10 years. Papillary carcinoma (PTC) is the most frequent form of thyroid carcinoma diagnosed after radiation exposure, with a higher prevalence of the solid subtype in young children with a short latency period and of the classical subtype in cases with a longer latency period after exposure. Molecular alterations, including intrachromosomal rearrangements, are frequently found. Among them, RET/PTC rearrangements are the most frequent. Current research is directed on the mechanism of genetic alterations induced by radiation and on a molecular signature that can identify the origin of thyroid carcinoma after a known or suspected exposure to radiation. Arch Endocrinol Metab. 2017;61(2):180-7.

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Section: Radiation-induced Thyroid Cancersupporting

confidence: 85%

Radiation exposure and thyroid cancer: a review

Iglesias

Schmidt

Ghuzlan

et al. 2017

Arch. Endocrinol. Metab.

163

View full text Add to dashboard Cite

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“…of many genes, which promotes cellular growth and survival [2][3][4][5]. Radiation exposure and iodine excess are the best-known predisposing factors for the development of PTC [6,7]. There is some evidence that high iodine exposure may be a driver event for transforming BRAF to a constitutively active state [7].…”

Section: Discussionmentioning

confidence: 99%

BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure

Özçelik

Bircan

Sarıkaya

et al. 2019

Endokrynologia Polska

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Introduction: BRAF V600E activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAF V600E mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure. Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAF V600E mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAF V600E mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000-2006) and long-term (2006-2012). Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAF V600E mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p = 0.002), vascular invasion (p = 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAF V600E mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%). Conclusion: We revealed that BRAF V600E mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAF V600E .

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“…It is well recognised that X-ray radiation exposure is associated with cancer development (7). Increased frequencies of basal cell carcinoma (8,9), thyroid carcinoma (1,6) and meningioma (5) have been shown in the tinea capitis cohorts.…”

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confidence: 99%