Radiation Therapy and Esophageal Cancer

Shridhar, Ravi; Almhanna, Khaldoun; Meredith, Kenneth; Biagioli, Matthew C.; Chuong, Michael D.; Cruz, Angie De La; Hoffe, Sarah E.

doi:10.1177/107327481302000203

Cited by 72 publications

(48 citation statements)

References 100 publications

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“…However, a large portion of ESCC tumors develop resistance to radiotherapy, indicating the importance to enhance the radiation sensitivity of ESCC. 1 Tumor hypoxia is known as an important factor leading to radiation resistance and poor clinical outcomes. 2,3 The oxygen occurred during radiotherapy generates free oxygen radicals that induce DNA damage and kill tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

Yang

Cai

et al. 2013

Cancer Biology & Therapy

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Radiation therapy is an important treatment approach for esophageal squamous cell carcinoma (ESCC). However, how to promote radiation sensitivity in ESCC remains a challenge. This study aimed to evaluate the effects of berberine, a common used Chinese medicine, on the radiosensitivity of ESCC. ECSS cell line ECA109 and TE13 were subjected to hypoxia and/or ionizing radiation (IR), in the presence or absence of berberine treatment. Cell growth and survival, and apoptosis were evaluated. In addition, ECA109 cells were xenografted into nude mice and subjected to IR and/or berberine treatment. The expression of HIF-1α and VEGF was detected by western blot and immunohistochemical analysis. Our results showed that berberine increased radiosensitivity of ESCC cells and xenografts, and this was associated with the inhibition of HIF-1α and VEGF expression. These data suggest that berberine may be a potential radiotherapy sensitization drugs due to its significant anti-hypoxia activity.

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Section: Introductionmentioning

confidence: 99%

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

Yang

Cai

et al. 2013

Cancer Biology & Therapy

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“…Radiotherapy is an essential therapy for the patients with inoperable and locally advanced esophageal cancer (Shridhar et al, 2013). However, a large portion of esophageal cancer tumors develop resistance to radiotherapy so its effect in these patients is limited.…”

Section: Discussionmentioning

confidence: 99%

miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4

Zhang¹,

Wang²,

Li³

et al. 2016

Genet. Mol. Res.

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“…Long term (5 years) locoregional control rates after radiotherapy and dCRT vary between 32% and 75%. In most trials, improved locoregional tumor control was associated to higher total radiation doses (4,20,21), concurrent chemotherapy (22), lower tumor volume (21), and SCC histology (22). However, improved locoregional tumor control after higher radiation doses at least in locally advanced oesophageal cancer seems not to translate into an improved OS (4,20).…”

Section: Definitive Crt Versus Preoperative Chemo/ Chemoradiotherapymentioning

confidence: 99%

Definitive chemoradiotherapy

Ståhl¹,

Budach²

2017

J. Thorac. Dis.

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Definitive chemoradiotherapy (dCRT) is reflecting a treatment standard in oesophageal cancer.For irresectable localised tumours and for inoperable patients, dCRT can change the treatment intent from palliative to curative. In patients with squamous cell carcinoma (SCC), in particular in those of cervical location, dCRT is a proper alternative for treatment that may include radical surgery. Patients with localised locoregional recurrence after primary surgery can survive for long-term after salvage CRT.

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Radiation Therapy and Esophageal Cancer

Abstract: Future directions will evaluate the benefit of induction chemotherapy followed by chemoradiotherapy, the role of surgery in locally advanced disease, and the identification of responders prior to treatment based on microarray analysis.

Cited by 72 publications

References 100 publications

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4

Definitive chemoradiotherapy

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