2012
DOI: 10.1093/jrr/rrs087
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Radiation therapy following surgery for localized breast cancer: outcome prediction by classical prognostic factors and approximatedgenetic subtypes

Abstract: The purpose of this study was to evaluate the outcome prediction power of classical prognostic factors along with surrogate approximation of genetic signatures (AGS) subtypes in patients affected by localized breast cancer (BC) and treated with postoperative radiotherapy. We retrospectively analyzed 468 consecutive female patients affected by localized BC with complete immunohistochemical and pathological information available. All patients underwent surgery plus radiotherapy. Median follow-up was 59 months (r… Show more

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Cited by 9 publications
(7 citation statements)
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“…In addition, to identify a predictive model for CSS and RFS an open source available package (Dose Response Explorer System), for combined modeling of multiple clinical factors using multiterm regression modeling was used. Briefly, the modeling process consists of a two‐step process.…”
Section: Methodsmentioning
confidence: 99%
“…In addition, to identify a predictive model for CSS and RFS an open source available package (Dose Response Explorer System), for combined modeling of multiple clinical factors using multiterm regression modeling was used. Briefly, the modeling process consists of a two‐step process.…”
Section: Methodsmentioning
confidence: 99%
“…Fly Genome-Wide Association Study (GWAS) for radiation-induced intestinal permeability. Genetic variations influence sensitivity to genotoxic stress, the detrimental effects of radiation treatment, and the prognosis of radiation therapy [78][79][80][81][82][83][84][85][86][87] . We leveraged the Drosophila Genetic Reference Panel (DGRP) that contains flies with fully sequenced genetic variations, to conduct an unbiased GWAS screening of approximately 156 fly strains from the DGRP.…”
Section: Ionizing Radiation Disrupts Intestinal Integrity and Inducesmentioning
confidence: 99%
“…The radiation treatment to the breast was delivered as previously described by three-dimensional conformal radiation (3D-CRT) therapy using two tangent 6 MV fields [14]. Plans were generated using a commercial treatment planning system (XiO 4.64, Elekta CMS) with the multigrid superposition dose calculation algorithm incorporating electron contamination component in the build-up region.…”
Section: Patients and Treatmentsmentioning
confidence: 99%