Radiation therapy for benign lymphoepithelial cysts of parotid glands in HIV patients

Abstract

RT provides a sustained long-term cosmetic control for BLEC of the parotid glands in HIV patients. Failures are uncommon, and the late side effects have been negligible.

Nonsurgical management of human immunodeficiency virus‐associated parotid cysts: A systematic review and meta‐analysis

“…Of local failure or recurrence, 78.1% (25/32) occurred in patients treated with low‐dose radiotherapy. Although there is a theoretical risk of radiation‐induced malignancy, this comprehensive review did not identify a specific case of salivary cancer secondary to radiotherapy in the setting of HIV‐associated parotid cyst management …”

“…Although there is a theoretical risk of radiation-induced malignancy, this comprehensive review did not identify a specific case of salivary cancer secondary to radiotherapy in the setting of HIV-associated parotid cyst management. 20,22 A variety of agents have been used for sclerotherapy, including sodium morrhuate, alcohol, doxycycline, bleomycin, and tetracycline. 10,11,[29][30][31][34][35][36][37] The mean complete response was roughly 53% for sclerotherapy across all studies.…”

“…Complete response was defined as a >75% reduction in the cystic lesion on radiographic imaging or complete clinical response/patient satisfaction; partial response was defined as a <75% reduction in the cystic lesion on radiographic imaging or limited clinical response/patient satisfaction. 20 Local failure was defined as persistent or enlarged parotid cyst or cosmetic dissatisfaction; recurrence was defined as enlarged parotid cyst determined by radiographic and/or clinical examination after complete response. Articles were excluded if the sample size was <5, subjective or objective outcome measures were not reported, data included non-HIV patients, or management methods were not specified.…”

Practical Imaging of the Parotid Gland

“…12 HIV-associated salivary gland disease is a spectrum of disease that includes persistent generalized lymphadenopathy, benign lymphoepithelial cysts (BLECs), mixed cystic and solid benign lymphoepithelial lesions (BLELs), and diffuse infiltrative lymphocytosis syndrome (DILS). Lymphoma might also be included in HIVassociated salivary gland disease.…”

DC-CIK biotherapy for a recurrent benign lymphoepithelial lesion of the salivary gland: A case report and literature review

“…At present, no standard therapy regimen is available for BLELs; however, glucocorticoid therapy, such as the administration of cyclophosphamide with prednisone, as an alternative to surgery has been reported ( 3 , 4 ). A recent study demonstrated that BLELs are sensitive to radiotherapy, which may be beneficial in recurrent lesions ( 5 ). Although surgery and radiation are the main treatment methods ( 6 – 9 ), BLELs of the salivary gland have been rarely studied and no common therapy criteria or adoptive cellular immunotherapy have been reported.…”