Radiation Therapy for Squamous Cell Carcinoma of the Tonsil

Foote, Robert L.; Hilgenfeld, R. U.; Kunselman, Susan J.; Schaid, Daniel J.; Buskirk, Steven J.; Grado, Gordon L.; Earle, John D.

doi:10.1016/s0025-6196(12)62242-3

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…The local control rates for patients with SCC of the tonsillar region after undergoing S ± RT (406 patients; 12% had T4 lesions) or RT alone (1833 patients; 14% had T4 lesions) are shown in Table 5. 21, 28, 41–53 Local control rates were similar (70% after S ± RT vs. 68% after RT; P = 0.2).…”

Section: Resultsmentioning

confidence: 74%

“…The local‐regional control rates for patients with SCC of the tonsillar region after undergoing S ± RT (281 patients) or RT ± ND (858 patients) are shown in Table 6. 41, 42, 48, 50, 52–57 A greater proportion of patients in the RT ± ND group had Stage IV disease (52% vs. 31%; P < 0.001). Despite this bias, local‐regional control rates (65% after S ± RT; 69% after RT ± ND) were similar ( P = 0.1).…”

Section: Resultsmentioning

confidence: 95%

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Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

410

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BACKGROUND The treatment of patients with squamous cell carcinoma (SCC) of the oropharynx remains controversial. No randomized trial has addressed adequately the question of whether surgery (S), radiation therapy (RT), or combined treatment is most effective. METHODS Treatment results from North American academic institutions that used S with or without adjuvant RT (S ± RT) or used RT alone or followed by neck dissection (RT ± ND) for patients with SCC of the tonsillar region or the base of tongue were compiled through a MEDLINE search (from 1970 to August, 2000) and from the references cited in each report. Studies were eligible for inclusion if they contained direct, actuarial (life‐table), or Kaplan–Meier calculations for the following end points: local control, local‐regional control, 5‐year absolute survival, 5‐year cause specific survival, or severe or fatal treatment complications. Weighted average results, which took into account series size, were calculated for each end point for the purposes of treatment comparison. Results and conclusions were based on data from 51 reported series, representing the treatment of approximately 6400 patients from the United States and Canada. RESULTS The results for patients with SCC of the base of tongue who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 79% versus 76% (P = 0.087); local‐regional control, 60% versus 69% (P = 0.009); 5‐year survival, 49% versus 52% (P = 0.2); 5‐year cause specific survival, 62% versus 63% (P = 0.4); severe complications, 32% versus 3.8% (P < 0.001); and fatal complications, 3.5% versus 0.4% (P < 0.001). The results for patients with SCC in the tonsillar region who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 70% versus 68% (P = 0.2); local‐regional control, 65% versus 69% (P = 0.1); 5‐year survival, 47% versus 43% (P = 0.2); 5‐year cause specific survival, 57% versus 59% (P = 0.3); severe complications, 23% versus 6% (P < 0.001); and fatal complications, 3.2% versus 0.8% (P < 0.001). CONCLUSIONS The information in this article provides a useful benchmark for evidence‐based counseling of patients with SCC of the oropharynx. The rates of local control, local‐regional control, 5‐year survival, and 5‐year cause specific survival were similar for patients who underwent S ± RT or RT ± ND, whereas the rates of severe or fatal complications were significantly greater for the S ± RT group. Furthermore, available data on the functional consequences of treatment suggest the superiority of RT ± ND. The authors conclude that RT ± ND is preferable for the majority of patients with SCC of the oropharynx. Cancer 2002;94:2967–80. © 2002 American Cancer Society. DOI 10.1002/cncr.10567

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Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 95%

Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

410

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“…The 5 year LRC of 88% in patients receiving initial surgery and PORT is at the higher end of the range (40–80%) of what is commonly quoted in the literature for surgery/PORT in locally advanced tonsil SCC 9–12 . The outcome was superior compared with patients treated with initial RT ± CT.…”

Section: Discussionmentioning

confidence: 80%

“…The 5 year OS of 56% was similar to other published series. Those receiving initial surgery had significantly superior survival compared with the initial RT group 10,11,15 …”

Section: Discussionmentioning

confidence: 99%

Locally Advanced Tonsillar Squamous Cell Carcinoma: Treatment Approach Revisited

Poulsen¹,

Porceddu

Kingsley³

et al. 2007

The Laryngoscope

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“…Advanced lesions (stage III and IV) are currently best treated with surgery followed by radiotherapy with or without chemotherapy 50,51 . Tumour size, extension and involvement of adjacent structures as well as surgeon preference dictate the surgical approach.…”

Section: Oropharyngeal (Tonsillar) Cancermentioning

confidence: 99%

Difficulties in the surgical management of head and neck cancer patient

Sarafoleanu

Vuzitas

Manea

2017

Romanian Journal of Rhinology

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Malignancies of the upper aerodigestive tract are high morbidity bearing and life-threatening diseases, which require thorough care from diagnostic suspicion and confirmation to surgical and/or oncologic treatment and rehabilitation. Difficulties in managing head and neck cancers arise from delays in diagnosis and treatment caused by either patient-related factors or healthcare system-related factors. Tumor origin and stage determine whether surgical excision is feasible, the approach required for safe excision, the extent of functional and aesthetic sacrifice required to attain oncologic safety and the need for reconstructive surgery. A thorough and systematic preoperative risk versus benefits assessment to select potential surgical candidates and give realistic outcomes is important from both a medical and a legal point of view. Because tumors in the head and neck region frequently involve more than one system and sensory organ, potential loss of function from either the disease course, surgical or nonsurgical treatment should be taken into account form a quality of life perspective. Effective management of head and neck cancer patients requires the cooperation and combined effort of a multidisciplinary team of surgeons, physicians and other workers over a long period of time which, in the absence of a specialised head and neck cancer centre and guidelines, can lead to increased morbidity and mortality, and patient dissatisfaction.

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Radiation Therapy for Squamous Cell Carcinoma of the Tonsil

Cited by 11 publications

References 25 publications

Squamous cell carcinoma of the oropharynx

Squamous cell carcinoma of the oropharynx

Locally Advanced Tonsillar Squamous Cell Carcinoma: Treatment Approach Revisited

Difficulties in the surgical management of head and neck cancer patient

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