Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control

Akimoto, Tetsuo; Nonaka, Tetsuo; Kitamoto, Yoshizumi; Ishikawa, Hitoshi; Ninomiya, Hiroshi; Chikamatsu, Kazuaki; Furuya, Nobuhiko; Hayakawa, Kazushige; Mitsuhashi, Norio; Nakano, Takashi

doi:10.1016/j.ijrobp.2005.10.003

Cited by 50 publications

(34 citation statements)

References 26 publications

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“…In short, we concluded that an improvement of CRT on LC of advanced head and neck cancers [1-5] had significant influence on the treatment of not only advanced cancers but also early GC in clinical practice in Japan. Several recent reports in Japan [21-26] have indicated that CRT for T2GC is promising and yields LC rates higher than those for RT alone. By means of these questionnaire surveys, we have demonstrated that CRT for T1 and T2 GC is used with the intent to improve LC in clinical practice at most institutions.…”

Section: Discussionmentioning

confidence: 99%

“…However, most otolaryngologists in Japan believe that LC by RT alone is insufficient in early stage GC [18-20]. Reports recently released by several institutes in Japan [21-26] have indicated that chemoradiation for T2GC is promising and yields LC rates higher than those for RT alone. Therefore, chemoradiation for bulky T1 and T2 GC is used to improve LC in clinical practice in Japan.…”

Section: Introductionmentioning

confidence: 99%

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Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

et al. 2012

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BackgroundThe purpose of this study is to analyze the outcome of patients with early glottic cancer (GC) treated with radiotherapy (RT) with or without chemotherapy at 10 institutions in the Tokai District, Japan.MethodsTen institutions combined data from 279 patients with T1-T2 GC treated with RT with or without chemotherapy between 2000 and 2005. The overall survival rate, disease-specific survival rate, and local control rate were evaluated in 270 patients, except for incomplete cases due to issues such as discontinuation, using the method of Kaplan-Meier and compared using the log-rank test. Results were considered statistically significant at the level of p < 0.05.ResultsFor 122 patients, the tumors were classified as T1a, while 64 patients had T1b tumors, and 84 patients had T2 tumors. In three cases of T1 tumors, the subtype was unknown. Combined chemoradiotherapy (CRT) was administered during each stage, and various chemotherapy drugs and regimens were used. The median follow-up period was 55.4 months. The 5-year LC rates for T1a, Tb, and T2 tumors in all patients were 87.9%, 82.7%, and 74.1%, respectively. The difference between T1a and T2 was statistically significant (p = 0.016). The 5-year LC rates for T1a, Tb, and T2 with CRT were 92.7%, 78.6%, and 80.7%, respectively, while the rates with radiation alone were 86.5%, 83.8%, and 64.4%, respectively. The difference between CRT and RT alone was not statistically significant in each stage.ConclusionsIn this survey, CRT was performed for early GC at most institutions in clinical practice. Our data showed no statistical difference in the LC rates between CRT and RT alone in each stage. However, there was a tendency for the LCRs of the CRT group to be more favorable than those of the RT group in the T2-stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

et al. 2012

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“…spite of their favorable initial response during RT. Akimoto et al 18 reported that CR was achieved in 60 (95%) of 63 patients with T2N0 glottic cancer 1 month after RT alone or CRT, whereas the recurrence was observed in 16 (27%) of 60 patients who showed CR. This indicates that initial tumor response may not predict the future local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…2 For the toxicity of concurrent CRT for T2N0 laryngeal cancer, Akimoto et al 18 reported that hematologic and nonhematologic toxicity of grade 3 was recognized in 11% and 7% of patients treated with RT with CDDP and/or docetaxel, respectively. Taguchi et al 19 also indicated that grade 3 toxicities in the patients treated with concurrent CRT using carboplatin and tegafur-uracil were recognized in 5% to 10% of patients with T2N0 glottic cancer.…”

Section: Discussionmentioning

confidence: 99%

Concurrent hyperfractionated radiotherapy and carboplatin with transoral debulking microsurgery for T2N0 glottic cancer

et al. 2008

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“…© 2011 To determine the optimal management strategy for head and neck cancers, both survival and the preservation of fundamental functions such as speech and swallowing have to be considered. Function-preserving therapies have been developed because of technological advances in surgery and radiation therapy as well as evolving evidence about the benefits of locoregional control of concomitant chemotherapy (Pignon et al 2000;Akimoto et al 2006;Salama et al 2007;Vermorken et al 2007;Posner et al 2007). However, it has become increasingly difficult to choose the optimal treatment option.…”

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confidence: 99%

Profiling of the Care Processes for Laryngeal Cancer with the Japanese Administrative Database

Ichimiya

Matsuda

Fujino

et al. 2011

Tohoku J. Exp. Med.

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At present, there is a shortage of detailed data on head and neck cancer treatment in acute care hospitals in Japan. We conducted an analysis of the care process for laryngeal cancer inpatients in Japan using a national administrative database based on the case-mix system known as the Diagnosis Procedure Combination to evaluate the recent clinical situation of a relatively high incidence of head and neck cancers. We obtained discharge data relating to 2790 cases (one case = one hospitalization) involving 2319 laryngeal cancer patients from 346 acute care hospitals that participated in the Japanese national case-mix project between July and December of 2008. The details of their treatment procedures were analyzed according to the Japanese procedure codes managed by the Ministry of Health, Labour, and Welfare of Japan. There were 2156 male and 163 female patients. The median age was 69 years (range: 22-96 years). The most frequent surgical procedure was endoscopic resection which was performed for 781 cases. Chemotherapy was given in 31.6% of cases in the < 60 age group, 28.2% in the 60-79, and 14.1% in the ≥ 80. The most frequently used chemotherapy regimen was a single drug, S-1 (compound of tegafur, gimeracil and oteracil potassium), which was more frequently used in the ≥ 70 age group than in the younger age group. The Diagnosis Procedure Combination database, which collects a large volume of data from all over the country, is useful for analysis of the care process for head and neck cancers in Japan.

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Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control

Cited by 50 publications

References 26 publications

Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

Concurrent hyperfractionated radiotherapy and carboplatin with transoral debulking microsurgery for T2N0 glottic cancer

Profiling of the Care Processes for Laryngeal Cancer with the Japanese Administrative Database

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