Radiation therapy for tumors of the pineal region

Salazar, Omar M.; Bakos, Robert; Vita, Hernan Castro; Rubin, Philip; Feldstein, Michael

doi:10.1016/0360-3016(78)90613-2

Cited by 5 publications

(14 citation statements)

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“…Total doses less than 45 Gy have been associated with inferior control rates of 50-60% as opposed to 80-90% in those patients receiving 50 Gy [10,11,21,36,37,52]. More recent reports favour a total dose of 45 Gy [40,42,48,53].…”

Section: Local Field Irradiationmentioning

confidence: 87%

“…Limited dose-response data supports a dose range of 45-55 Gy at 1.8 Gy per fraction to restricted radiation fields (whole brain or VS followed by boost to tumour or ventricle, or smaller fields restricted only to local tumour or ventricle) [1,8,9,21,25,26,36,37] (Table IV). Total doses less than 45 Gy have been associated with inferior control rates of 50-60% as opposed to 80-90% in those patients receiving 50 Gy [10,11,21,36,37,52].…”

Section: Local Field Irradiationmentioning

confidence: 91%

“…When compared to smaller radiation therapy fields, WBRT was shown to provide better results in one centre where CT scan and MRI were not routinely available [37]. Others have also reported more favourable results following WBRT [24,28,37,47]. Some have quoted intracranial recurrence rates of up to 15% when full cranial irradiation was not utilised [24,48,49].…”

Section: Local Field Irradiationmentioning

confidence: 94%

Section: Local Field Irradiationmentioning

confidence: 96%

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Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Borg¹

2003

Med. Pediatr. Oncol.

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The excellent outcome in children with pure germinoma of the CNS and the long-term morbidity associated with standard therapy justifies attempts to limit both the total radiation dose and field sizes, with or without the addition of chemotherapy. The poorer outcome associated with non-germinoma GCT justifies a more aggressive approach in children, combining chemotherapy, surgery and virgule, or radiation therapy, based on known prognostic factors.

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Section: Local Field Irradiationmentioning

confidence: 87%

Section: Local Field Irradiationmentioning

confidence: 91%

Section: Local Field Irradiationmentioning

confidence: 94%

Section: Local Field Irradiationmentioning

confidence: 96%

See 2 more Smart Citations

Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Borg¹

2003

Med. Pediatr. Oncol.

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“…According to the review of Salazar et al [2,18] , a radiation dose of more than 20 Gy to the spinal vertebrae will arrest bone growth in young children. CSI necessitates treatment down to the second sacral vertebra, and scattered radiation to the gonads may lead to undesirable disorders of conception [5] .…”

Section: Discussionmentioning

confidence: 99%

Dual Occurrence of Pineal Germinoma and Testicular Seminoma

Ho¹

2005

Pediatr Neurosurg

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A 16-year-old male presented with obstructive hydrocephalus secondary to pineal germinoma. There have been many reported cases of abdominal metastasis of pineal germinoma after ventriculoperitoneal shunting. Endoscopic ventriculostomy was preferred in our case, thus avoiding iatrogenic peritoneal seeding, but spinal metastasis was unavoidable. Metastatic infiltration of the ventricular system and spinal meninges is the commonest mode of spread. Later, the patient underwent orchidectomy for an asymptomatic left testicular seminoma. He responded to chemotherapy, and had a complete recurrence-free remission for more than 10 years. As far as we know there are only a handful of reported cases of dual occurrence of two primary germ cell tumors (GCT), i.e. gonadal seminoma and pineal germinoma with spinal seeding. We also addressed the controversial subject of radiation versus chemotherapy in the management of patients with pineal germinomas. A review of the relevant literature and recommendations for future treatment of similar cases are discussed.

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Primary intracranial germinoma with massive ventriculoperitoneal shunt metastases

Talamo

Mendelow

1985

Journal of Surgical Oncology

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Ventriculoperitoneal shunt metastases from primary intracranial germinomas are extremely rare. To date, only three case reports of this phenomenon have appeared in the literature. We present the case of a 25-year-old black male who developed ventriculoperitoneal shunt metastases 10 months following diagnosis of an intracranial germinoma. Radiotherapy destroyed most of the intracranial tumor, but abdominal metastases became progressive and were not treated with radiotherapy. The role of radiotherapy in the treatment of ventriculoperitoneal shunt metastases is examined and previous cases in the literature are reviewed.

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Radiation therapy for tumors of the pineal region

Cited by 5 publications

References 0 publications

Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Dual Occurrence of Pineal Germinoma and Testicular Seminoma

Primary intracranial germinoma with massive ventriculoperitoneal shunt metastases

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