Radiation Therapy in Conjunction With Surgical Stabilization of Impending or Pathologic Fractures Secondary to Metastasis: Is There a Difference Between Single and Multifraction Regimens?

Abstract

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Skeletal-Related Events After Surgery With or Without Radiotherapy for Bone Metastases to Weight-Bearing Bones

“…As PORT is considered the standard of care, much of the research has related to the ideal dose and fractionation, which is also unclear in the literature. Two recent studies indicate different results, specifically that a single fraction is equivalent to multiple fractions [21] and, alternatively, that PORT using 30 Gy in 10 fractions is preferred [22].…”

ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases

“…The role of postoperative radiotherapy in patients with surgically stabilized metastatic bone disease has been shown in a retrospective study in which recovery of normal functional status was significantly better for the group having surgery plus postoperative radiotherapy compared to radiotherapy only [93]. A second retrospective study has confirmed this effect [94]. However, it should be noted that the quality of evidence is low, due to the design of both studies (Willeumier et al 2016).…”