Radiation therapy in inverted papillomas of the nasal cavity and paranasal sinuses

Gómez, Juana; Mendenhall, William M.; Tannehill, Scott P.; Stringer, Scott P.; Cassisi, Nicholas J.

doi:10.1016/s0196-0709(00)85020-6

Cited by 38 publications

(28 citation statements)

References 28 publications

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“…Intranasal lesions of neoplastic conditions may present as typical firm proliferative lesions with destruction of surrounding structures or may mimic inflammatory conditions in their early stages with the presence of polyps on endoscopy. Patients of slow growing conditions like inverted papilloma due to their appearance invariably present with repeated polypectomies done prior to a definitive diagnosis being reached [13].…”

Section: Discussionmentioning

confidence: 99%

A Review of the Clinicopathological and Radiological Features of Unilateral Nasal Mass

Nair

James

Awasthi

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Unilateral sinonasal pathology are common presentations but are regarded with caution as neoplastic conditions during their early stages may mimic an inflammatory pathology. The aim of the review was to analyse the varied presentations of patients with unilateral nasal mass and to identify features suggestive of neoplastic pathology. A retrospective review of all cases of unilateral nasal mass/polyp from Jan 09 to Jan 10 presenting at a tertiary care hospital were analysed. The patients were grouped as per their histopathological diagnosis as inflammatory and neoplastic. The demographic data, presenting symptoms, radiological and histopathological findings were compared between the two groups. Out of the 53 patients of unilateral nasal mass, 44 (83.1%) had inflammatory conditions and 9 (16.9%) had neoplastic conditions. Benign nasal polyp and inverted papilloma were the commonest inflammatory and neoplastic condition. Neoplastic conditions were significantly commoner in males (P = 0.0315) and in the age group above 50 years (P = 0.0046). Epistaxis and extranasal symptoms like facial pain, dental and orbital complaints were found to be significantly higher in neoplastic conditions. Neoplastic lesions of nose and paranasal sinus are one of the most challenging conditions that otolaryngologists have to diagnose and treat due to their hidden nature and late presentations. In our review neoplastic conditions were found to be higher in elderly male with epistaxis, extranasal symptoms and presence of extensive soft tissue involvement and bony destruction on CT scan. The clinician should have a high index of suspicion to rule out a neoplastic aetiology in all cases of unilateral nasal mass.

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Section: Discussionmentioning

confidence: 99%

A Review of the Clinicopathological and Radiological Features of Unilateral Nasal Mass

Nair

James

Awasthi

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…There has been some concern with the use of radiation therapy for the treatment of IP without an associated malignancy. A study by Gomez et al reported 4 out of 14 patients treated for benign disease with radiation therapy (98). Two other studies by Weissler et al and Mendenhall et al have shown no conversion to malignancy and excellent control rates (35,99).…”

Section: Surgical Advancesmentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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“…The second reason, also originated in the past when imaging and RT were much less sophisticated and effective than nowadays, would be the opinion that RT is ineffective in preventing recurrences. Recently, modern radiologic techniques allow even better visualization of the extent of tumors and more effective planning of surgical procedures [8]. In review of the literature for irradiation of benign IPs, we found only six studies with, in total, 16 patients describing necessary details on therapy and outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Because only two cases with neck metastases of benign-appearing IPs have been reported so far, no elective irradiation of regional lymphatics is needed. In order to improve the therapeutic outcomes, novel RT techniques have been proposed, including intensity-modulated RT with image guidance, and hyperfractionation of RT dose with increased dose conformity [7,8].…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for Inverted Papilloma of the Nasal Cavity: A Rare Case Report and Review of the Literature

et al. 2017

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Inverted papilloma or Schneiderian papilloma arising primarily from middle ear and mastoid is a very rare entity. It is a benign and locally aggressive condition, with increased risk of recurrence and malignant transformation. Surgery is the primary treatment and radiation therapy should be considered in case of malignant transformation, recurrent or inoperable disease. Here we report a case of recurrent inverted papilloma with dysplastic changes arising from nasal cavity in a 56-year-old male. The patient was treated with surgery followed by radiotherapy.

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Radiation therapy in inverted papillomas of the nasal cavity and paranasal sinuses

Cited by 38 publications

References 28 publications

A Review of the Clinicopathological and Radiological Features of Unilateral Nasal Mass

A Review of the Clinicopathological and Radiological Features of Unilateral Nasal Mass

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Radiotherapy for Inverted Papilloma of the Nasal Cavity: A Rare Case Report and Review of the Literature

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