Radiation Therapy in Thymoma

Optimal delineation of the clinical target volume for thymomas in the post-resection setting: A multi-center study

“…11 Currently, a lack of a standardized protocol for PORT in thymomas leads to only brief advice in international guidelines. 5,8 These results support our findings that a protocol and further research in optimal delineation of CTVs for thymomas in the post-resection setting is necessary.…”

“…PORT in stage II thymomas remains controversial, but may be considered in B2/B3 thymomas with a R0-resection. [5][6][7][8] PORT is associated with a prolonged overall survival (OS) and recurrence-free survival (RFS), especially in stage III/IV thymomas. 5,9,10 Accurate delineation of tumor volumes is a time-consuming and crucial step in radiotherapy, but it is also the most susceptible to human error.…”

Immune checkpoints in thymic epithelial tumors: challenges and opportunities

“…Surgery is the mainstay of curative-intent treatment in limited-stage tumors, as complete resection represents the most favorable prognostic factor for overall survival in both thymomas and thymic carcinomas [7]. Postoperative radiotherapy is debated after complete resection of thymomas, but has been associated with better outcome in thymic carcinomas [8]. Systemic treatment may be delivered in a curative-intent approach for patients presenting with locally advanced tumors at the time of diagnosis, with invasion of intrathoracic neighboring structures and/or dissemination to the pleura and the pericardium, precluding complete resection.…”