Radiation Therapy of Carcinoma of the Tonsillar Region

Fayos, Juan V.; Lampé, I

doi:10.2214/ajr.111.1.85

Cited by 40 publications

(10 citation statements)

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“…The local control rates for patients with SCC of the tonsillar region after undergoing S ± RT (406 patients; 12% had T4 lesions) or RT alone (1833 patients; 14% had T4 lesions) are shown in Table 5. 21, 28, 41–53 Local control rates were similar (70% after S ± RT vs. 68% after RT; P = 0.2).…”

Section: Resultsmentioning

confidence: 74%

Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

409

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BACKGROUND The treatment of patients with squamous cell carcinoma (SCC) of the oropharynx remains controversial. No randomized trial has addressed adequately the question of whether surgery (S), radiation therapy (RT), or combined treatment is most effective. METHODS Treatment results from North American academic institutions that used S with or without adjuvant RT (S ± RT) or used RT alone or followed by neck dissection (RT ± ND) for patients with SCC of the tonsillar region or the base of tongue were compiled through a MEDLINE search (from 1970 to August, 2000) and from the references cited in each report. Studies were eligible for inclusion if they contained direct, actuarial (life‐table), or Kaplan–Meier calculations for the following end points: local control, local‐regional control, 5‐year absolute survival, 5‐year cause specific survival, or severe or fatal treatment complications. Weighted average results, which took into account series size, were calculated for each end point for the purposes of treatment comparison. Results and conclusions were based on data from 51 reported series, representing the treatment of approximately 6400 patients from the United States and Canada. RESULTS The results for patients with SCC of the base of tongue who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 79% versus 76% (P = 0.087); local‐regional control, 60% versus 69% (P = 0.009); 5‐year survival, 49% versus 52% (P = 0.2); 5‐year cause specific survival, 62% versus 63% (P = 0.4); severe complications, 32% versus 3.8% (P < 0.001); and fatal complications, 3.5% versus 0.4% (P < 0.001). The results for patients with SCC in the tonsillar region who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 70% versus 68% (P = 0.2); local‐regional control, 65% versus 69% (P = 0.1); 5‐year survival, 47% versus 43% (P = 0.2); 5‐year cause specific survival, 57% versus 59% (P = 0.3); severe complications, 23% versus 6% (P < 0.001); and fatal complications, 3.2% versus 0.8% (P < 0.001). CONCLUSIONS The information in this article provides a useful benchmark for evidence‐based counseling of patients with SCC of the oropharynx. The rates of local control, local‐regional control, 5‐year survival, and 5‐year cause specific survival were similar for patients who underwent S ± RT or RT ± ND, whereas the rates of severe or fatal complications were significantly greater for the S ± RT group. Furthermore, available data on the functional consequences of treatment suggest the superiority of RT ± ND. The authors conclude that RT ± ND is preferable for the majority of patients with SCC of the oropharynx. Cancer 2002;94:2967–80. © 2002 American Cancer Society. DOI 10.1002/cncr.10567

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Section: Resultsmentioning

confidence: 74%

Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

409

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“…The 5 year OS of 56% was similar to other published series. Those receiving initial surgery had significantly superior survival compared with the initial RT group 10,11,15 …”

Section: Discussionmentioning

confidence: 99%

Locally Advanced Tonsillar Squamous Cell Carcinoma: Treatment Approach Revisited

Poulsen¹,

Porceddu

Kingsley³

et al. 2007

The Laryngoscope

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“…Dental disease is relatively common after irradiation of the oropharynx in people owing to periodontal membrane damage and changes in saliva. 40 The rapid growth of melanomas often prevents prophylactic treatment. This was the case in the two dogs that developed complications after therapy.…”

Section: Discussionmentioning

confidence: 99%

0–7–21 Radiation Therapy for the Treatment of Canine Oral Melanoma

Bateman

Catton

Pennock

et al. 1994

Veterinary Internal Medicne

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Eighteen dogs with malignant melanoma of the oral cavity were treated with high-dose per fraction (0-7-21 ) radiation therapy. Eight hundred cGy was administered on days 0,7, and 21 for a total dose of 2,400 cGy in 3 weeks. Of 1 7 dogs evaluated, 9 (53%) had a complete remission and 5 (30%) achieved a partial remission with an overall response rate of 83%. Local failure occurred in 2 of the 9 dogs where a complete response was initially observed. One dog died of intercurrent disease, and one died of metastatic disease without evidence of local recurrence. Five dogs are alive elanomas are the most common oropharyngeal ma-

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Radiation Therapy of Carcinoma of the Tonsillar Region

Cited by 40 publications

References 0 publications

Squamous cell carcinoma of the oropharynx

Squamous cell carcinoma of the oropharynx

Locally Advanced Tonsillar Squamous Cell Carcinoma: Treatment Approach Revisited

0–7–21 Radiation Therapy for the Treatment of Canine Oral Melanoma

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