Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy

Abstract

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Comparison of Breast Cancer Radiotherapy Techniques Regarding Secondary Cancer Risk and Normal Tissue Complication Probability – Modelling and Measurements Using a 3D-Printed Phantom

“…3D-CRT was the treatment standard until the 2010s but is increasingly being replaced by IMRT or VMAT, especially due to the higher computing power of the available computer hardware and improved planning software (6,7). With regard to an additional dose saturation of the tumour bed, external irradiation procedures are available on the one hand, for example additive percutaneous irradiation sessions (sequential boost) following the total breast irradiation (WBI) or by means of a simultaneous integrated boost (SiB), in which the boost saturation is included in the percutaneous WBI (8)(9)(10)(11). On the other hand, boost treatment can be applied by means of brachytherapy (12), e.g., using the afterloading technique with interstitial catheters, so that the additional desired dose can be deposited in the tumour bed over the course of several treatment sessions.…”

Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes

“…New radiation techniques, such as intensity modulated radiotherapy and volumetric modulated arc therapy, have been introduced, with increased sparing of surrounding healthy tissue. To our knowledge, an effect of such technical modifications on OS in patients with rectal cancer has not been described, but intensity modulated radiotherapy was associated with fewer grade 3 or greater adverse events in endometrial cancer based on the PORTEC-3 trial . Lastly, a significant proportion of the causes of death were unknown, especially in the 2011 cohort, of which a part still could have been oncological mortality.…”

Postoperative Radiotherapy for Endometrial Cancer in Elderly (≥80 Years) Patients: Oncologic Outcomes, Toxicity, and Validation of Prognostic Scores

“…Furthermore, from a radiation oncologist view, there has been great RT technique development over the assessed time of the last 15 years. The application of the standard technique has today changed from 3D-RT into widespread advanced IMRT, that has been proven to improve bone marrow sparing and more conformal target coverage and thus to be associated with lower gastrointestinal and hematologic toxicity than 3D-RT without diminishing the oncologic outcome [ 43 ]. The use of above-mentioned BT or the application of smaller pelvic RT volumes can be options to spare toxicity [ 44 ] and are even more attractive in the treatment of the very elderly, but those de-escalation strategies should be used after reasonable case evaluation only.…”