Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study

Ciernik, I. Frank; Dizendorf, Elena; Baumert, Brigitta G.; Reiner, Beatrice Simcox; Burger, Cyrill; Davis, J.B.; Lütolf, Urs M.; Steinert, H.; Schulthess, Gustav K. von

doi:10.1016/s0360-3016(03)00346-8

Cited by 482 publications

(294 citation statements)

References 37 publications

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“…However, when used together MRI, CT, and PET each can add complimentary data to improve tumor delineation [25]. While most studies examining PET alone based GTVs are usually smaller then their counterpart CT based GTVs, in ∼25% of patients of cases the additional information obtained from PET can increase the GTV compared to CT alone based GTVs [10][11][12][13]15,[26][27][28]. In addition, this number can increase to up to 64% depending on the SUV threshold used [28].…”

Section: Discussionmentioning

confidence: 99%

“…Such areas could be part of a simultaneous integrated boost [32,33]. It is unclear whether these targets for dose escalation should be defined by, visual interpretation [11], a threshold intensity plateau [28], or if the boost dose intensity should be specifically tailored to each imaging voxel intensity (i.e. painting by numbers) [34].…”

Section: Discussionmentioning

confidence: 99%

“…FDG-PET uptake may be a surrogate for hypoxia and it has been shown to predict treatment response and loco regional failure (LRF) [7][8][9]. In addition, FDG-PET defined tumor volumes have been reported to be smaller than CT defined ones [10][11][12][13][14][15] and several others have suggested PET alone based methods to define the GTV. An examination of the exact site of LRF relative to pre-treatment PET defined target may shed light on the utility of PET as a vehicle to define the GTV.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Soto¹,

Kessler²,

Piert³

et al. 2008

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Soto¹,

Kessler²,

Piert³

et al. 2008

Radiotherapy and Oncology

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show abstract

“…We chose the most intense point on each malignant lesion and drew the lesion boundaries using SUV-based contouring software. A fixed 50 % of local maximum intensity was used as the threshold intensity value, and this was deemed reasonable from previous studies [16][17][18]. When the automated software included not only malignant lesions but also background activity, we manually removed the background boundaries by reviewing the background CT findings.…”

Section: Image Interpretation and Quantitationmentioning

confidence: 99%

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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Purpose The aim of this study was to evaluate the relationship between semiquantitative parameters on 18 F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18 F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18 F-FDG PET/ CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p= 0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of 18 F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18 F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

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“…18 F-FDG PET/CT is emerging as a potentially valuable technique in radiotherapy planning, as well as in the prediction and evaluation of response to therapy 1124. The use of 18 F-FDG PET/CT for preoperative radiotherapy planning in rectal cancer significantly alters both the gross tumor volume and the clinical target volume, with a mean increase in size of 25% and 4%, respectively 25…”

Section: Methodsmentioning

confidence: 99%

¹⁸F-FDG PET/CT Imaging In Oncology

Almuhaideb

Παπαθανασίου

Bomanji

2011

Annals of Saudi Medicine

286

123

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Accurate diagnosis and staging are essential for the optimal management of cancer patients. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) has emerged as a powerful imaging tool for the detection of various cancers. The combined acquisition of PET and CT has synergistic advantages over PET or CT alone and minimizes their individual limitations. It is a valuable tool for staging and restaging of some tumors and has an important role in the detection of recurrence in asymptomatic patients with rising tumor marker levels and patients with negative or equivocal findings on conventional imaging techniques. It also allows for monitoring response to therapy and permitting timely modification of therapeutic regimens. In about 27% of the patients, the course of managment is changed. This review provides guidance for oncologists/ radiotherapists and clinical and surgical specialists on the use of 18F-FDG PET/CT in oncology.

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Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study

Cited by 482 publications

References 37 publications

Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

¹⁸F-FDG PET/CT Imaging In Oncology

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Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study

Cited by 482 publications

References 37 publications

Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

18F-FDG PET/CT Imaging In Oncology

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¹⁸F-FDG PET/CT Imaging In Oncology