Radical and Superoxide Scavenging Activities of Matairesinol and Oxidized Matairesinol

Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7′-Oxodihydroguaiaretic Acid

“…This result is same as that from a previous study on tetrahydrofuran and butyrolactone lignans. [3][4][5] It could be assumed that the oxygen-free benzylic position of lignan is important for the reaction with DPPH. In the test for production of ethyl linoleate hydroperoxide, (À)-DGA and (À)-SECO were stronger inhibitors of the production of hydroperoxide than (+)-ODGA (Fig.…”

“…In our previous study, the higher degree of benzylic oxidation of tetrahydrofuran and butyrolactone lignan decreased the antioxidant activity. [3][4][5] The purpose of this research on butane-type lignans is to determine the effect of benzylic oxidation on the antioxidant activity. As well as the chemical antioxidant activity, the lipoxygenase inhibition activities of both enantiomers of SECO, DGA and ODGA were evaluated in this study (Fig.…”

IgE-Suppressive Activity of (−)-Matairesinol and Its Structure-Activity Relationship

“…12) All stereoisomers and derivatives were prepared by the previously described method. [7][8][9][10] The enantiomeric excess of all stereoisomers of matairesinol prepared by the previous method was determined as more than 99%ee by using a chiral column. Assay of the IgM productive activity.…”

“…The stereoisomers of matairesinol and derivatives were synthesized by the previously described method. [7][8][9][10] Since IgE is an antibody for allergy, suppressing the activity of IgE-production would decrease the allergic symptoms, while promotive compounds would contribute to research into allergy. The IgM-and IgE-productive activities of secoisolariciresinol, which is a butanediol type of lignan contained in food plant, were examined in our previous study, and the IgM-accelerative production of (À)-and (þ)-secoisolariciresinol was observed; however, none of the stereoisomers of secoisolariciresinol affected the IgE-productive activity.…”

Immunomodulatory Effect of (−)-Matairesinolin Vivoandex Vivo

“…3,4) Mat is converted to enterolactone by mammalian gut microflora after its ingestion. 5,6) Mat and its metabolite enterolactone have been reported to possess antioxidative 7,8) and estrogenic or anti-estrogenic activities. 9,10) Furthermore, their positive effect on reducing the risk of hormone-dependent cancer has recently been demonstrated.…”