Radical chemoradiotherapy for elderly patients with bladder carcinoma invading muscle

Arias, Fernando; Dueñas, Mayte; Martı́nez, Enrique; Dominguez, Miguel A.; Illarramendi, José Juan; Villafranca, E.; Tejedor, M. Cristina; Molina, Francisco; Meiriño, R.; Valerdi, Juan José

doi:10.1002/(sici)1097-0142(19970701)80:1<115::aid-cncr15>3.0.co;2-0

Cited by 22 publications

(4 citation statements)

References 21 publications

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“…Turgeon and Souhami 20 conducted a review of the use of TMT for MIBC in elderly patients, in which they presented a table of outcomes and toxicity data from 8 publications and 4 conference abstracts, summing to a total of 496 elderly patients. [21][22][23][24][25][26][27][28][29][30][31][32] Although the definition of "elderly" is variable in the literature, Turgeon and Souhami reported the most common definition of elderly to be those aged 70 years, which was used in greater than one-half of the studies reviewed. The median reported age of patients in the reviewed studies was 78 years.…”

Section: Discussionmentioning

confidence: 99%

Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy

Korpics

Block

Martin

et al. 2017

Cancer

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Section: Discussionmentioning

confidence: 99%

Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy

Korpics

Block

Martin

et al. 2017

Cancer

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“…El principal factor pronóstico relacionado con el paciente es su performance status, ya que condiciona no sólo la posibilidad de tratamientos radicales (cirugía o quimioradioterapia) sino también la respuesta a los mismos. La edad, tradicionalmente considerada como de peor pronóstico, hoy no se considera un factor determinante, considerándose más importante el estado general del paciente que el que éste sea mayor 12 . Otros parámetros del paciente como el estado inmunitario, el nivel de hemoglobina, los niveles de fosfatasa alcalina sérica, se relacionan más con el performance status por lo que en la actualidad no pueden ser considerados factores pronósticos.…”

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Prognostic factors in urological tumours

Dueñas

Arias²,

Arcos³

et al. 2009

An Sist Sanit Navar

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Urological tumours are a heterogeneous group of neoplasms developed from the urinary tract. They include tumours of the prostate, bladder and kidney. Their incidence is high, especially amongst males, and they have different clinical courses, prognoses and treatments. This article reviews the most important prognostic factors for predicting the evolution of the neoplasm and its possibility of cure.

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“…Through a lot of basic research, the molecular mechanism of 125 I particles in radiotherapy for malignant tumor has achieved certain results in the induction of tumor cell apoptosis and cell cycle arrest, intracellular signal transduction and inhibition of tumor angiogenesis. In patients with recurrent bladder cancer, the efficacy of the general chemotherapy regimen is limited ( 3 ). In this study, we implanted 125 I radioactive particles into the tumor, and observed the clinical efficacy of this treatment modality during recurrent bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of therapeutic effects of 125I particles brachytherapy for recurrent bladder cancer

et al. 2017

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The aim of the present study was to evaluate the clinical value of 125I particles implantation in the treatment of recurrent bladder cancer. The study is a retrospective analysis of 32 patients with recurrent bladder cancer treated between May 2010 and January 2010. Of these, 16 cases (chemotherapy group) received conventional chemotherapy. A total of 16 patients (125I group) received radiotherapy with 125I particles, followed by conventional chemotherapy. By guidance of B ultrasound, 125I radioactive particles were implanted. All 32 patients were relieved after treatment, and the tumors were significantly reduced after 2 months. However, the tumors in the 125I group were significantly smaller than those in the chemotherapy group (P<0.05). The patients were followed-up for 1 year and no recurrence was found. Additionally, no complications occurred. Compared with the chemotherapy group, the tumor volume of the 125I group was significantly reduced (P<0.05). The disease-free survival and 5-year survival rates of the patients in the follow-up showed that the disease-free survival and 5-year survival rates of the patients in 125I group were significantly improved compared to those in the chemotherapy group. Therefore, the results have shown that 125I radioactive particles in the treatment of bladder cancer improve the symptoms of patients with bladder cancer in the short term, and continuously kill residual tumor and prevent recurrence.

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Radical chemoradiotherapy for elderly patients with bladder carcinoma invading muscle

Abstract: The age of the individual must not become a strict exclusion criterion for the radical treatment of old patients with invasive bladder carcinoma.

Cited by 22 publications

References 21 publications

Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy

Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy

Prognostic factors in urological tumours

Evaluation of therapeutic effects of 125I particles brachytherapy for recurrent bladder cancer

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