Radical cystectomy is the treatment of choice for invasive bladder cancer

Yafi, Faysal A.; Kassouf, Wassim

doi:10.5489/cuaj.1156

Cited by 14 publications

(8 citation statements)

References 38 publications

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“…RC has long been recommended as the ‘gold standard’ treatment for patients with MIBC, as well as being indicated for high-risk and recurrent NMIBC [1] , [17] . Published series report favourable survival outcomes after RC for MIBC when compared to bladder preservation treatments such as radical radiotherapy, transurethral resection of bladder tumours, and local chemotherapy [17] , [18] , [19] . Patients being managed conservatively could potentially lead to multiple hospital admissions with complications of bladder cancer such as haematuria, leading to significant anaemia, and bladder dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Radical cystectomy in the elderly – Is this a safe treatment option?

Young

Elmussareh

Weston

et al. 2017

Arab Journal of Urology

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ObjectiveTo determine if significant differences exist in the perioperative outcomes of patients aged >75 years treated with radical cystectomy (RC) compared to younger patients, as RC is frequently not offered to ‘elderly’ patients with bladder cancer because of supposed increased risks of complications.Patients and methodsWe retrospectively analysed prospectively collected data of all patients that underwent RC in our centre from May 2013 to June 2015. In all, 81 consecutive RCs were identified and included in our study. Patients were divided into two age groups: Group A, aged <75 years (51 patients) and Group B, aged ≥75 years (30). Co-morbidities and perioperative outcomes were compared between the groups. Fisher’s exact test was used for statistical analysis.ResultsIn 68 patients RC was performed laparoscopically and the remaining 13 patients underwent open RC. The mean (range) age was 70.7 (36–85) years. There were 37 patients with muscle-invasive disease and 42 had non-muscle-invasive disease. The median hospital stay was not significantly different between the two age groups (10 vs 11 days). There was no significant difference in the preoperative Charlson co-morbidity index. The 30-day mortality rate was 4% for those aged <75 years and 6.6% for those aged ≥75 years, with overall perioperative complication rates of 57% vs 66%, respectively. Most complications were minor (Clavien–Dindo Grade I–II) and there was no statistically significant difference between the two cohorts. There was also no statistically significant difference in blood transfusion rates.ConclusionRC in patients aged ≥75 years has similar perioperative morbidity when compared with younger patients and can be offered in selected elderly patients. Thus, age should not be an absolute contraindication for RC.

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Section: Discussionmentioning

confidence: 99%

Radical cystectomy in the elderly – Is this a safe treatment option?

Young

Elmussareh

Weston

et al. 2017

Arab Journal of Urology

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“…After a moment of silence, Professor Kamlesh started telling Ms. Revati about the tumour of the bladder as seen in the MRI report. With much compassion and confidence, he said, "Madam, ideally radical cystectomy, which means the removal of the urinary bladder with pelvic lymph node (the cancer cells usually transfer to this area first) dissection, is the standard treatment for patients with invasive bladder cancer, followed by chemo and radiotherapy [25]. But considering her age and functional status, I will go for a diagnostic cystoscopy, which means that we have to get adequate amount of tissue to diagnose and characterise the tumour.…”

Section: Comprehensive Geriatric Assessment: the Best Tool To Assess mentioning

confidence: 99%

Panorama of Cancer

Chatterjee

2019

Health and Wellbeing in Late Life

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Panorama of Cancer "Everything was fine till yesterday, but today I came to know that my tissue has turned out to be positive for cancer. After retirement, I started my second innings with lot of aspiration, enjoying with my grandchildren, teaching the underprivileged school students in our colony, doing Yoga with peer groups and many more fun activities. Suddenly everything collapsed. I lost my jijivisha, my desire to live. But few questions are haunting me day and night: Why me? I never indulged in any kind of addiction. I had been doing regular exercise throughout my life. My parents didn't have cancer. Even the doctor couldn't answer my query; he is only preparing me and my family to fight the battle".-Mr. Naresh Pandita, a 70-year-old retired bureaucrat, shared his agony when he came to see me to manage his newly diagnosed cancer of lung. I believe these are the thoughts that commonly occupy a person who is newly diagnosed with cancer.

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“…1 The incidence and burden on the health care system are increasing. [2][3][4][5][6] It is well-established that tobacco use is the cause of bladder cancer in one-third to one-half of CaB cases, [7][8][9] yet CaB related to tobacco use is still rising. [9][10][11] Continued tobacco use following a CaB diagnosis has also been associated with worse disease-associated outcomes, such as tumour recurrence, progression to invasive disease and metastases, and the acquisition of secondary urinary tract carcinomas.…”

Section: Introductionmentioning

confidence: 99%