Radical scavenger activity of bendazac, an anticataract non-steroidal anti-inflammatory agent

Characterization of a novel process-related impurity in commercial bendazac lysine eye drops by LC–ESI-QTOF/MS/MS and NMR

“…1 H NMR experiments were carried out at 600 MHz, while 13 C NMR experiments were performed at 150 MHz. Proton and carbon chemical shifts were reported on ı scale in ppm, relative to tetramethyl silane (TMS) (ı = 0.00 ppm) and acetonitrile (ı = 1.94 ppm) as internal standards in 1 H and 13 C NMR spectra respectively.…”

“…1A) [1]. Its principal effects are to inhibit the denaturation of proteins and aldose reductase activity [2].…”

Synthesis and in vitro antitumor and antimicrobial activity of some 2,3-diaryl-7-methyl-4,5,6,7-tetrahydroindazole and 3,3a,4,5,6,7-hexahydroindazole derivatives

“…The indazole ring system is regarded as a bioisostere of indole. However, a large number of synthetically prepared indazoles are known to show a variety of biological activities, such as high binding affinity for estrogen receptor 1,2 , inhibition of protein kinase C-β 3 , 5-HT2 receptor agonism 4 , human immunodeficiency virus (HIV) protease inhibition 5 , anti-leukemic activity 6 , and non-steroidal anti-inflammatory activity 7 . Other compounds of interest are YC-1, a benzylindazole which has been shown to activate soluble guanylate cyclase 8 , nitric oxide synthase inhibition activity 9,10 , to induce cellular apoptosis 11 and a MCHr1 antagonism for the treatment of obesity 12 .…”

Bendazac Lysine Inhibition of Human Lens Epithelial Cell Adhesion to Polymethylmethacrylate Intraocular Lenses

“…Bendazac is an anti-inflammatory drug endowed with protein-stabilizing properties and antioxidant activity [16][17][18][19][20][21]. Bendazac protects proteins from aggregation due to the interaction of the electrostatic groups of polypeptidic chains and from denaturation induced by different chemical and physical agents.…”