Radical scavenging activities of Tyr-, Trp-, Cys- and Met-Gly and their protective effects against AAPH-induced oxidative damage in human erythrocytes

Zheng, Lin; Dong, Hongzhu; Su, Guowan; Zhao, Qiangzhong; Zhao, Ming

doi:10.1016/j.foodchem.2015.11.012

Cited by 63 publications

(51 citation statements)

References 29 publications

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“…Wiriyaphan et al (Wiriyaphan et al, 2013)determined the antioxidant activity of peptides derived from the product of threadfin bream surimi, and the results demonstrated that the decreasing ferric antioxidant power of peptide was closely related to the amounts of Trp, Met and Cys. Zheng et al (Zheng et al, 2016)discovered that the antioxidant behaviours of peptides strongly depended on the compositions and reactionsof the amino acid residues, and the Cys could effectively scavenge DPPH radicals, which was consistent with our result, while Tyr, Trp and Gly showed a little or even no DPPH radical scavenging activities. Triantis et al (Triantis et al, 2007)found that Cys contained one free -SH group, this free -SH group had strong electron-donating ability and hydrogen-donating ability, this may be the reason why cysteine has high antioxidant capacity.…”

Section: Oxygen Radical Absorbance Capacity Assaysupporting

confidence: 92%

Enhancing the in vitro Antioxidant Capacities via the interaction of amino acids

Liu¹,

Wang

2018

Emir J Food Agric

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In this article, antioxidant capacities of 20 amino acids were quantitatively determined via methodology of mixing one amino acid with the others and using four antioxidant assays to understand the synergistic effects of the individual amino acid contributing to the total antioxidant capacity. Some of the individual amino acids and their mixtures showed their characteristics of antioxidant capacities, and antioxidant peptides showed different results in different experiments. From the ABTS assay study, it was found that nine of 20 amino acids had antioxidant capacities, and most of their mixtures had synergetic effects, Moreover, an oxygen radical absorbance capacity assay study was conducted, and the results aligned well with the ABTS study. However, the DPPH and FRAP assay studies, indicated that cysteine was the only amino acid having antioxidant effect in 20 amino acids. The result showed that the combinations of high antioxidant amino acids and weak antioxidant amino acids or non-antioxidant amino acids led to an obvious increase in antioxidant capacity compared with the theoretical antioxidant capacity.

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Section: Oxygen Radical Absorbance Capacity Assaysupporting

confidence: 92%

Enhancing the in vitro Antioxidant Capacities via the interaction of amino acids

Liu¹,

Wang

2018

Emir J Food Agric

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“…Pretreatment of manuka honey (0.1%) for 24 h at 37 °C improved the CAT and SOD activities in 10 mM AAPH‐stressed primary human dermal fibroblasts (HDFa), and curcumin, cyanidin‐3‐rutinoside, and 5‑hydroxymethylfurfural (5‐HMF) increased the SOD activity in erythrocytes while antcin C from Antrodia cinnamomea developed the protein expression level of SOD in HepG2 cells (Gokila Vani and others ; Zhang and others ; Alvarez‐Suarez and others ). However, compared with the AAPH‐untreated erythrocytes, the CAT levels of erythrocytes treated with AAPH alone, or with AAPH and dipeptides within 3 h did not significantly change, which might be due to the limited H 2 O 2 level obtained by the AAPH‐induced oxidative stress (Zheng and others ). Meanwhile, AAPH treatment (200 mM) significantly increased the activities of SOD, GPx, and CAT in erythrocytes, while the diosmetin treatment (100 μg/mL) decreased the activities of GPx, SOD, and CAT to a normal level (Liao and others ).…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 89%

“…H 2 O 2 ‐induced oxidant stress can lead to inflammation. Anthocyanin‐rich phenolic extracts of purple pretreatment significantly reduced H 2 O 2 ‐induced (1 mM for 6 h) IL‐1β, IL‐6, and IL‐8 activities in Caco‐2 cells (Zhang and others ). Caco‐2 cells were pretreated with pyranoanthocyanins and other polyphenols from staghorn sumac ( Rhus hirta L .)…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 92%

“…However, blood samples collected after feeding with antioxidants for a period and oxidized with multiple oxidants have also been used (Tulipani and others ). For the cell cultures, erythrocytes were isolated by centrifugation at 3000 × g for 10 min and washed 4 times with PBS at pH 7.4, and then resuspended to the desired hematocrit level in the same buffer (Hseu and others ; Zheng and others ).…”

Section: Evaluation Of Antioxidant Capacity In Cultured Cellsmentioning

confidence: 99%

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Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Zhang

Yin

Huang

et al. 2017

Journal of Food Science

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The mechanisms of antioxidant activities of phytochemicals are highly complex, so various methods to study them have been developed. However, the diverse available methods show inconsistent results. Different stressors, cell models, and animal models have been used to evaluate the antioxidant properties of phytochemicals. However, the literature still lacks a summary of the effects of different stressors, cell models, and animal models on the evaluation of antioxidant activities. Therefore, the mechanisms of action of different oxidative stimuli and the characteristics of the available cell models and animal models are summarized in this review.

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“…The protective effects on AAPH‐induced erythrocytes haemolysis expressed as antihaemolysis activity value were determined using the method of Zheng et al . ().…”

Section: Methodsmentioning

confidence: 97%

Monomeric phenolics in different parts of high‐acid apple (Malus sieversii f. niedzwetzkyana (Dieck) Langenf): a promising source of antioxidants for application in nutraceuticals

Lin

Yang

et al. 2018

Int J of Food Sci Tech

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Summary The high‐acid apple (Malus sieversii f. niedzwetzkyana (Dieck) Langenf) possessing deep red peel and light red flesh is widely distributed in China. To determine if a useful apple variety is being ignored, the monomeric phenolic profiles and antioxidant activities of peel, flesh, pomace, whole fruit and juice were evaluated. The results were compared to those of ‘Fuji’ and ‘Granny Smith’ apples. The high‐acid apple possessing the highest total phenolic and anthocyanin contents among three apple varieties contained the most chlorogenic acid, phloridzin, epicatechin, ferulic acid, catechin, vanillic acid, p‐coumaric acid and caffeic acid. The extraction yields of phenolics (64%) and anthocyanins (89%) from the high‐acid apple to juice were the highest. The high‐acid apple possessing the greatest antioxidant activity had the strongest antihaemolysis activity, indicating that it could be used to produce juice and value‐added ingredient to assist in the prevention of chronic disease.

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Radical scavenging activities of Tyr-, Trp-, Cys- and Met-Gly and their protective effects against AAPH-induced oxidative damage in human erythrocytes

Cited by 63 publications

References 29 publications

Enhancing the in vitro Antioxidant Capacities via the interaction of amino acids

Enhancing the in vitro Antioxidant Capacities via the interaction of amino acids

Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Monomeric phenolics in different parts of high‐acid apple (Malus sieversii f. niedzwetzkyana (Dieck) Langenf): a promising source of antioxidants for application in nutraceuticals

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