Radical-scavenging activity of extracts from Cordia verbenacea DC obtained by different methods

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)

“…Methanol extract of C. verbenacea and the rosmarinic acid isolated from it inhibited the oedema induced by snake venom of Bothrops C. platythyrsa Anti-inflammatory The methanol extract of the bark showed significant anti-inflammatory effect in carrageenaninduced rat paw oedema [178] Analgesic The methanol extract of the bark demonstrated analgesic activity against various models of pain such as writhing test, tail flick, thermal hyperalgesia, mechanically induced pain and formalin-induced pain in rats [178] C. rothii Immunomodulatory Ethyl acetate fraction and n-hexane fraction obtained from leaves were reported to have immunomodulatory effect in phytohaemagglutinin (PHA)-stimulated T-cell proliferation, oxidative burst and nitric oxide (NO) assays [93] Antidiabetic The ethanol extract of the bark produced significant hypoglycaemic effect in rats [191] Wound healing Topical application of the extract prepared from leaves showed improved wound healing in rats [193] C. rufescens Immunomodulatory Chloroform and ethyl acetate extract of the aerial parts demonstrated immunomodulatory activity in mouse lymphocytes and macrophages [217] C. salicifolia Antiviral Partially purified extract of whole plant displayed antiviral against herpes simplex virus type 1 [218] Antioxidant A methanol fraction of the leaves showed potent free radical scavenging and xanthine oxidase inhibitory activity [221] C. sebestena Antidiabetic The ethanol extract of the leaves was active in reducing hyperglycaemia and liver glycogen level in streptozotocin-induced diabetes in rats [193] Antibacterial The ethyl acetate extract showed strong antibacterial activity against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa [205] C. spinescens Anti-HIV The water extract of the leaves was reported to have potent inhibitory action on HIV reverse transcriptase enzyme with IC 50 values of 6-8 lg/ml [134,219] C. superba Immunomodulatory Chloroform and ethyl acetate extract of the aerial parts demonstrated immunomodulatory activity in mouse lymphocytes and macrophages [217] C. verbenacea Antimicrobial The essential oil obtained from aerial parts and leaves was found to have antimicrobial activity against Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis, and yeast, but it was inactive against Gram-negative bacteria. A hexane extract of the leaves also shown antibacterial activity against Staphylococcus aureus [42,137,145,162,163,175] Antioxidant The ethyl acetate extract and the extract obtained by SFE using a 25% aqueous mixture of ethanol was found to have potent antioxidant activity ...…”

Determinação do perfil fitoquímico de extrato com atividade antioxidante da espécie medicinal Cordia verbenacea DC. por HPLC-DAD

“…Na medicina popular é utilizada na forma de chá via oral, a partir das folhas, por apresentar efeito anti-inflamatório, antiartrítico, analgésico, tônico e antiulcerogênico. O uso externo do chá é empregado como cicatrizante de feridas e úlceras (Lorenzi & Matos, 2008 Michielin et al (2011), foram produzidos extratos das folhas de C. verbenacea obtidos por diferentes métodos extrativos sendo, posteriormente, submetidos a ensaios antioxidantes. Como resultado, observou-se que a atividade antioxidante foi mais potente nos extratos polares.…”

Investigation of the Antioxidative Potential of Various Solvent Fractions From Fruiting Bodies of Schizophyllum commune (Fr.) Mushrooms and Characterization of Phytoconstituents

“…In this process, double bonds of lipids undergo rearrangements that result in destruction of lipids, producing breakdown products, such as malondialdehyde. Thus the estimation of malondialdehyde in a mushroom fraction helps to evaluate its protection level against lipid peroxidation, (i.e., antioxidants present in sample protect against the hazardous effects of free radicals on unsaturated fatty acids, minimizing the production of malondialdehyde) (Michielin et al, 2011). In our study, lipid peroxidation induced by Fe 2+ was estimated by the presence of TBARS.…”