Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel

Khader, Syed Zameer Ahmed; Ahmed, Sidhra Syed Zameer; Arunachalam, Thangakumar; Nayaka, Sanjeeva; Balasubramanian, Senthil Kumar; SyedAmeen, Syed Tajudeen; Ponmurugan, P.

doi:10.1016/j.bfopcu.2018.02.001

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…Similarly, the results of hydroxyl radical scavenging activity demonstrates that AgNPs synthesised from dates extract exhibited maximum activity (78.7%) at 10mg concentration (Figure 6). Many research has stated that various medicinal plants and their products has confirmed to be a potential to radical scavenger and has the ability to combat against various diseases (Khader et al, 2018b;Syed et al, 2019b;Sidhra et al, 2017). DPPH, FRAP and OH radicals are frequently used in research to identify the scavenging potential, in the present study the radicals produced are scavenged by the synthesized AgNPs from Rothan date seeds by donating electrons and making it a more stable compound.…”

Section: Effect Of In Vitro Radical Scavenging Activity Of Agnpsmentioning

confidence: 99%

“…Research has proved that inflammation is the primary physiological defense mechanism against different stimuli and proteins denaturation is the primary cause for the onset of inflammation and arthritic diseases (Khader et al, 2018b). The inflammatory response is due to the cellular activity caused by action of lysosomal enzymes to an external stimuli.…”

Section: Anti-inflammatory and Antiarthritic Activity On Synthesized ...mentioning

confidence: 99%

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In vitro anti-inflammatory, anti-arthritic and anti- proliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)

Khader¹,

Ahmed²,

Mahboob³

et al. 2022

Braz. J. Pharm. Sci.

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Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by ( 111), ( 200), ( 220) and ( 222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR-TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC 50 value of 59.66 μg/mL expressing the potential of AgNPs to combat cancer.

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Section: Effect Of In Vitro Radical Scavenging Activity Of Agnpsmentioning

confidence: 99%

Section: Anti-inflammatory and Antiarthritic Activity On Synthesized ...mentioning

confidence: 99%

In vitro anti-inflammatory, anti-arthritic and anti- proliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)

Khader¹,

Ahmed²,

Mahboob³

et al. 2022

Braz. J. Pharm. Sci.

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“…Extraction of phytochemicals from the plants was performed using the method described by Syed et al (2017Syed et al ( , 2018. Extraction was carried out by dissolving 10gms of herbal powder in 100 mL of Methanol and kept on an orbital shaker for 48 h. Then the extract was filtered using Whattman filter paper No.…”

Section: Extractionmentioning

confidence: 99%

Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa, Centella asiatica and Azadirachta indica as a wound dressing material

Ahmed¹,

Balu²,

Khader³

et al. 2020

ADV TRADIT MED (ADTM)

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Biomaterials are used on wounds as a dressing material to prevent the infection and to heal the wounds. In this present study, pure bamboo fabric has been selected for construction of functional part of bandage, coated with natural herbs such as Azadirachta indica, Centella asiatica, and Curcuma longa by microcapsules and exhaustion method. The binding of extracts to the fabric was confirmed through FTIR and FESEM analysis at 1 µm magnification. The air-permeability of the fabricate samples shows 100 cm 3 /cm 2 /s and the bursting strength was found to be 5.5 kg/cm 2 . The extension at break and recover of fabricated material was 101% and 24% respectively. The extract coated fabric expressed good water contact angle (50.51°-58.69°) and swelling property of about 337-320% at 10 mg/ml extract concentration. All fabrics exhibited good antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, the major microbes present in the wounds. The prepared dressing material had shown only 20% degradation against lysozyme enzyme with no allergic reactions. Furthermore, wound healing ability of BFC-Cl, BFC-Ai and BFC-Ca were tested on Albino Wistar rats and found that extracts coated fabric took 15 days for complete healing of wound.

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“…), iii) 16, 17-dihydro-12β, 16β-epoxynapelline, and iv) 12-epi-napelline and 12-epi-dehydronapeline, respectively. Some of these alkaloids have been demonstrated to have anti-rheumatic effects ( 9 ). Therefore, further in-depth investigation is required to identify the unknown components in the Aconitum soongoricum Stapf.…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory and anti‑rheumatic activities in vitro of alkaloids separated from Aconitum soongoricum Stapf

et al. 2021

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The aim of the present study was to investigate the cell proliferation-inhibiting and anti-rheumatic activities of chemical components from Aconitum soongoricum Stapf. Chemical constituents of Aconitum soongoricum Stapf. were separated and purified by silica gel and Sephadex LH-20 chromatography. Structure was identified by spectroscopic technique, and physical/chemical properties were analyzed. The following four compounds were identified: i) Aconitine, ii) songorine, iii) 16, 17-dihydro-12β, 16β-epoxynapelline, and iv) 12-epi-napelline. Cell Counting kit-8 assay was performed to assess cell proliferation. ELISA was conducted to determine the cytokine contents, and reverse transcription-quantitative polymerase chain reaction and Western blot analysis were performed to detect the mRNA and protein expression levels. Compared with the lipopolysaccharide (LPS) group, the contents of IL-6, IL-1β, TNF-α and PGE-2 in the culture supernatant were significantly declined in the leflunomide + LPS and intervention+LPS groups, as well as the mRNA expression levels of HIF-1α, VEGFA and TLR4. Treatments with songorine, benzoylaconine and aconitine (at different concentrations) significantly inhibited the proliferation of HFLS-RA cells. Compared with the LPS group, the contents of PGE-2, IL-6, IL-1β and TNF-α in the culture supernatant were significantly decreased in the intervention groups, and the mRNA expression levels of TLR4, HIF-1α and VEGFA in the cells in the intervention groups. Songorine, benzoylaconine and aconitine from Aconitum soongoricum Stapf. have anti-rheumatic activities in vitro , which may inhibit the proliferation of HFLS-RA cells, and the underlying mechanisms may be associated with inhibiting the inflammatory cytokine production and downregulating the expression levels of HIF-1α, VEGF and TLR4.

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Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel

Cited by 19 publications

References 18 publications

In vitro anti-inflammatory, anti-arthritic and anti- proliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)

In vitro anti-inflammatory, anti-arthritic and anti- proliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)

Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa, Centella asiatica and Azadirachta indica as a wound dressing material

Anti‑inflammatory and anti‑rheumatic activities in vitro of alkaloids separated from Aconitum soongoricum Stapf

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