Radical Scavenging Properties of Indapamide and Renal Protection in Dahl Salt-Sensitive Rats.

Uehara, Yoshio; Kawabata, Yusuke; Shirahase, Hiroaki; Wada, Kazuo; Hashizume, Yukiko; Morishita, Shinya; Numabe, Atsushi; Iwai, Junichi; Matsuoka, Hiroaki; Sugimoto, Tsuneaki

doi:10.1291/hypres.15.17

Cited by 22 publications

(9 citation statements)

References 24 publications

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“…The latency time more than 400 secs was considered as maintaining the memory. Journal of Biosciences and Medicines generation in whole-brain homogenates [22] [23]. Briefly, the entire brain was isolated, rinsed with ice-chilled fresh Dulbecco's phosphate-buffered solution (D-PBS), and quickly homogenized in 50 mmoles/L D-PBS, pH 7.4, at 4˚C using a Polytron ultrasonic blender (Central Scientific Commerce, Inc., Tokyo, Japan).…”

Section: Evaluation Of Oxidative Stress In the Brainmentioning

confidence: 99%

Fructose-Induced Cognitive Dysfunction is Associated with Increased Oxidative Stress in the Rat Brains

Yabe¹,

Yamakawa²,

Tomari³

et al. 2018

JBM

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High fructose consumption is a risk factor for diabetes. Type 2 diabetes is associated with cognitive and memory impairment. To determine if fructose intake might affect memory function independently of diabetes development, we investigated the effects of monosaccharides on memory in prediabetic state. We examined whether 2.5% apple juice solution could influence cognitive function in salt-sensitive Dahl rats using passive avoidance methods. Furthermore, we examined the role of monosaccharides intake in cognitive function and oxidative stress in the brain. Four-week consumption of either apple juice or 2.5% fructose did not affect the blood glucose concentrations; however, apple juice, but not fructose, significantly decreased cognitive function compared with that of control rats given water. Second, Wistar rats aged 4 weeks were assigned to four groups given water, or 1.25% glucose, or fructose, or galactose solutions for 11 weeks. The fructose group had only slightly higher blood glucose concentrations than the control group. However, memory function engraved at age of 7 weeks and evaluated for 8 weeks in a passive avoidance test, was significantly decreased in the fructose and galactose groups compared with those in the glucose group. Oxidative stress in the brain, assessed by the tissue malondialdehyde (MDA) content, was significantly increased in the fructose group compared with that in the control group, and the decrease in cognitive function significantly correlated with the MDA content. These findings suggest that long-term apple juice consumption decreases memory function, possibly through an increase in oxidative stress in the brain, in turn induced by fructose overloading. Fructose-induced cognitive dysfunction is likely mediated by mechanisms other than insulin resistance.

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Section: Evaluation Of Oxidative Stress In the Brainmentioning

confidence: 99%

Fructose-Induced Cognitive Dysfunction is Associated with Increased Oxidative Stress in the Rat Brains

Yabe¹,

Yamakawa²,

Tomari³

et al. 2018

JBM

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“…To assess the antioxidant effects of dilazep, we measured plasma and urinary concentrations of lipid peroxides as malon-dialdehyde (MDA), an endproduct of lipid peroxides, according to the method previously reported (17). Briefly, 1 ml plasma or urine was mixed with 5 ml of 20% trichloracetic acid and vigorously vortexed.…”

Section: Measurement Of Lipid Peroxidesmentioning

confidence: 99%

“…To assess renal function, we determined plasma and urinary levels of creatinine, plasma levels of electrolytes, and urinary protein excretions as reported previously (4,13,14,17).…”

Section: Functional and Morphological Alterations Of The Kidneymentioning

confidence: 99%

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Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5 g/ml in drinking water) or high-dose dilazep (12.5 g/ml).

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“…Various antihypertensive drugs have been reported to prevent the morphological changes of the arteries in experimental hypertension (12)(13)(14). Angiotensin-converting enzyme (ACE) inhibitors consistently prevent impaired arterial function (9,15,16).…”

mentioning

confidence: 99%

Protective Effects of Iganidipine on Morphological and Functional Changes of Arteries in Hypertensive Dahl Rats

Shirahase

Uehara

Kanda

et al. 1998

J Cardiovasc Pharmacol Ther

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BACKGROUND: This study was performed to examine the protective effects of iganidipine, a new water-soluble calcium antagonist, on the morphological and functional changes of arteries in Dahl salt-sensitive (Dahl-S) rats. METHODS AND RESULTS: Vehicle and iganidipine were administered orally to Dahl-S rats fed a high-salt diet (HSD) for 8 weeks. Aorta, superior mesenteric arteries (SMA), and peripheral mesenteric arteries (PMA) were examined light-microscopically or electon-microscopically. Relaxant responses of isolated aorta and SMA were recorded isometrically. In rats fed HSD, blood pressure was markedly increased. Light microscopy showed intimal and medial hypertrophy, periarteritis, and narrowed arterial lumen in the PMA. Transmission and scanning electron microscopy or light microscopy showed medical thickness in the aorta and SMA and hypertrophy of endothelial cells and dilatation of the subendothelial space only in the aorta. In the SMA, both endothelium-dependent relaxation (EDR) and endothelium-independent relaxations (EIR) were reduced to a similar extent. In the aorta, the EDR was more markedly attenuated than the EIR. Iganidipine at 3 mg/kg/day showed a 24-h sustained hypotensive effect and completely prevented the morphological and functional changes in both arteries. Iganidipine at 1 mg/kg/day, which lowered blood pressure only for several hours, decreased the injuries in PMA and aortic endothelium and moderately restored the EDR in the aorta. Iganidipine at 0.3 mg/kg/day had no effects. CONCLUSIONS: In Dahl-S rats fed an HSD, iganidipine completely prevented all the changes at a sustained-hypotensive dose and prevented the injuries of PMA and aortic endothelium and the reduction of EDR in the aorta at a nonsustained hypotensive dose. Nonhemodynamic effects of iganidipine may be partly involved in its protective effects against arterial injuries.

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Radical Scavenging Properties of Indapamide and Renal Protection in Dahl Salt-Sensitive Rats.

Cited by 22 publications

References 24 publications

Fructose-Induced Cognitive Dysfunction is Associated with Increased Oxidative Stress in the Rat Brains

Fructose-Induced Cognitive Dysfunction is Associated with Increased Oxidative Stress in the Rat Brains

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Protective Effects of Iganidipine on Morphological and Functional Changes of Arteries in Hypertensive Dahl Rats

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