Radical Surgery and Postoperative Split-Course Radiotherapy in Squamous Cell Carcinoma of the Head and Neck—Factors Influencing Local Control and Survival

Feasibility and Efficacy of Accelerated Weekly Concomitant Boost Postoperative Radiation Therapy Combined with Concomitant Chemotherapy in Patients with Locally Advanced Head and Neck Cancer

“…6 Various strategies have been proposed to improve the outcome. [7][8][9][10] Two major approaches have gained importance in recent years to improve the outcomes: altered fractionation and concomitant CT regimens. Confirming expectations based on radiobiological theory, altered fractionation regimens could overcome accelerated tumor population, and concurrent delivery of CT and ionizing radiation could sensitize tumor clonogens.…”

Evaluation of purely accelerated six fractions per week radiotherapy in postoperative oral cavity squamous cell carcinoma

“…The appropriate dose, fractionation, and OTTs for different risk categories of postoperative OCSCC patients continue to be a matter of scientific deliberation and evaluation. Treatment intensification has been attempted in postoperative OCSCC by different methods, including accelerated PORT by concomitant boost techniques, using acceleration with CTRT, split‐course RT, and IMRT techniques (Table ). Although there are several published studies on acceleration in PORT with or without chemotherapy, there is lack of literature addressing purely accelerated PORT.…”

Intraoperative Radiotherapy (IORT) with Low-Energy Photons as a Boost in Patients with Early-Stage Oral Cancer with the Indications for Postoperative Radiotherapy

“…Complementary radiotherapy usually includes dose escalation (boost) to the areas, where the risk of recurrence is considerable. The most popular techniques of boost delivery include additional EBRT fractions given in conventional, accelerated or concomitant schedule [1,9,13,20,30], brachytherapy and some IORT techniques [5,8,11,13,16,20,23,33].…”

“…For the majority of these lesions, surgery is preferred with excellent results. In some cases, however, complementary radiotherapy is indicated due to the high risk of local recurrence [2,7,13,22,23,28,29]. In this group of patients, similarly to more advanced cases, postoperative external-beam radiotherapy (EBRT) is often employed with escalated dose to the tumor bed (boost) [1,13,18,20,25,30].…”

“…In some cases, however, complementary radiotherapy is indicated due to the high risk of local recurrence [2,7,13,22,23,28,29]. In this group of patients, similarly to more advanced cases, postoperative external-beam radiotherapy (EBRT) is often employed with escalated dose to the tumor bed (boost) [1,13,18,20,25,30]. There are different techniques of boost delivery [5,8,9,11,16,17,21,24,26,33] and intraoperative radiation therapy (IORT) is one of them.…”