Radical treatment of extensive nevoid hyperkeratosis of the areola and breast with surgical excision after mild response to topical agents: A case report

Abstract

HighlightsThe extensive variant of NHNA affects the areolas and largely peri-areolar skin.Lesions tend to recur with conservative management (topical agents).Surgical treatment can be offered as a safe and radical therapeutic option.

Nevoid hyperkeratosis of the nipple mimicking a seborreic keratosis

“…Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is an uncommon skin disease with an unknown etiology in which the nipple and/or areola are covered with diffuse, hyperpigmented, verrucous, and asymptomatic plaques 1,2 most predominant in the female gender between puberty and the third decade. 3 We report a rare case of unilateral lesion on the nipple clinically and dermoscopically identical to a seborreic keratosis. Nevertheless, histopathologic examination suggested the diagnosis of NHNA.…”

Cutaneous Disorders of the Breast

“…Cryotherapy (Lee et al 2005b) and carbon dioxide laser (Busse et al 1999) give better results. Shave excision (Swan et al 2004), tangential excision using a radiofrequency surgical unit (Singh 2016), and removal of the areola and reconstruction with a skin graft (Tocco-Tussardi et al 2016;Foustanos et al 2012) are performed with success. • Differential diagnosis: Acanthosis nigricans, inadequate hygiene, and ichthyosis.…”

Bilateral nipple neoformations

“…The associated dermatitis neglecta is related to a lack of hygiene in the affected areas, resulting in hyperpigmented and adherent scales. 2 Darier disease—Incorrect. Darier disease is an autosomal dominant genodermatosis.…”