Radical Vaginal Trachelectomy

Speiser, Dorothee; Köhler, Christian; Schneider, Achim; Mangler, Mandy

doi:10.3238/arztebl.2013.0289

Cited by 11 publications

(5 citation statements)

References 42 publications

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“…Data on nearly 1,500 cases have been published, mostly from European countries, Japan, the US, Canada, China, and Argentina 28–33. A vaginal approach to radical trachelectomy was undertaken in about two thirds of these cases, and approximately 300 pregnancies resulting in live births, half being premature, have been reported 34. An abdominal approach to trachelectomy was undertaken in the remaining 485 cases.…”

Section: Fertility-sparing Surgerymentioning

confidence: 99%

“…28 – 33 A vaginal approach to radical trachelectomy was undertaken in about two thirds of these cases, and approximately 300 pregnancies resulting in live births, half being premature, have been reported. 34 An abdominal approach to trachelectomy was undertaken in the remaining 485 cases. Although 413 of these women were regarded as fertile after the procedure, only 113 (38%) attempted a pregnancy and 67 achieved a live birth (59.3%).…”

Section: Fertility-sparing Surgerymentioning

confidence: 99%

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Fertility preservation during cancer treatment: clinical guidelines

Rodriguez‐Wallberg¹,

Oktay²

2014

CMAR

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The majority of children, adolescents, and young adults diagnosed with cancer today will become long-term survivors. The threat to fertility that cancer treatments pose to young patients cannot be prevented in many cases, and thus research into methods for fertility preservation is developing, aiming at offering cancer patients the ability to have biologically related children in the future. This paper discusses the current status of fertility preservation methods when infertility risks are related to surgical oncologic treatments, radiation therapy, or chemotherapy. Several scientific groups and societies have developed consensus documents and guidelines for fertility preservation. Decisions about fertility and imminent potentially gonadotoxic therapies must be made rapidly. Timely and complete information on the impact of cancer treatment on fertility and fertility preservation options should be presented to all patients when a cancer treatment is planned.

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Section: Fertility-sparing Surgerymentioning

confidence: 99%

Section: Fertility-sparing Surgerymentioning

confidence: 99%

Fertility preservation during cancer treatment: clinical guidelines

Rodriguez‐Wallberg¹,

Oktay²

2014

CMAR

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“…9,11,20,21 Patients who have infertility after trachelectomy already presented impaired fertility before the operation in most of the patients. 5,21 Pregnancy after RVT is associated with an elevated risk of preterm birth. One third of deliveries occur before the gestational week 32, of which another one third take place before the gestational week 28.…”

mentioning

confidence: 99%

Pattern of Cancer Recurrence in 320 Patients After Radical Vaginal Trachelectomy

Mangler

Lanowska

Köhler

et al. 2014

Int J Gynecol Cancer

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“…Of those abstracts, 130 full texts were scrutinised, and 51 failed to meet the inclusion criteria, leaving 79 studies for inclusion in our analysis. 25 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , …”

Section: Resultsmentioning

confidence: 99%

Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review

Yong

Cooper

Yorke

et al. 2022

BJOG

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Background: Cervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility-sparing surgery is an appealing option where possible. However, absence of large-scale data, along with a notable variation in reported outcomes in relevant studies, may undermine future efforts for consistent evidence synthesis. Objectives: To systematically review the reported outcomes measured in studies that include women who underwent fertility-sparing surgery for cervical cancer and identify whether variation exists. Search strategy: We searched MEDLINE, EMBASE and CENTRAL from inception to February 2019. Selection criteria: Randomised controlled trials, cohort and observational studies, and case studies of more than ten participants from January 1990 to date. Data collection and analysis: Study characteristics and all reported treatment outcomes. Main results: A total of 104 studies with a sum of 9535 participants were identified. Most studies reported on oncological outcomes (97/104), followed by fertility and pregnancy (86/104), postoperative complications (74/104), intra-operative complications (72/104) and quality of life (5/104). There was huge variation and heterogeneity in reported outcomes, with only 12% being good quality and 87% being of poor quality. Conclusions: There is significant heterogeneity in the reported outcomes. An agreed Core Outcome Set is necessary for future studies to effectively harmonise reported outcomes that are measurable and relevant to patients, clinicians and researchers. This systematic review sets the groundwork for the development of a Core Outcome Set for fertility-sparing surgery in cervical cancer.

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Radical Vaginal Trachelectomy

Cited by 11 publications

References 42 publications

Fertility preservation during cancer treatment: clinical guidelines

Fertility preservation during cancer treatment: clinical guidelines

Pattern of Cancer Recurrence in 320 Patients After Radical Vaginal Trachelectomy

Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review

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